A comparison of the radiation sensitivities of non-tumorigenic and tumorigenic human hybrid cell lines

M. Colman, S. Bhatt, M. Candelaria, C. Sun, J. L. Redpath

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The radiation sensitivities of two related non-tumorigenic and two related tumorigenic human hybrid cell lines (HeLa × skin fibroblast) have been studied. The data show that the transformation from the non-tumorigenic to the tumorigenic state, which is accompanied by the loss of skin fibroblast chromosomes 11 and 14, is not associated with any major changes in radiation sensitivity. The data do indicate, however, a trend toward a steeper and longer initial slope to the cell survival curve for the tumorigenic cell lines, along with a subsequent reduced ability to accumulate sublethal radiation injury at low doses. Both non-tumorigenic and tumorigenic cell lines have the capability of repairing sublethal injury.

Original languageEnglish (US)
Pages (from-to)609-616
Number of pages8
JournalInternational Journal of Radiation Biology
Volume53
Issue number4
DOIs
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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