A comprehensive review of the nasal microbiome in chronic rhinosinusitis (CRS)

M. Mahdavinia, A. Keshavarzian, M. C. Tobin, A. L. Landay, R. P. Schleimer

Research output: Contribution to journalReview articlepeer-review

111 Scopus citations


Chronic rhinosinusitis (CRS) has been known as a disease with strong infectious and inflammatory components for decades. The recent advancement in methods identifying microbes has helped implicate the airway microbiome in inflammatory respiratory diseases such as asthma and COPD. Such studies support a role of resident microbes in both health and disease of host tissue, especially in the case of inflammatory mucosal diseases. Identifying interactive events between microbes and elements of the immune system can help us to uncover the pathogenic mechanisms underlying CRS. Here we provide a review of the findings on the complex upper respiratory microbiome in CRS in comparison with healthy controls. Furthermore, we have reviewed the defects and alterations of the host immune system that interact with microbes and could be associated with dysbiosis in CRS.

Original languageEnglish (US)
Pages (from-to)21-41
Number of pages21
JournalClinical and Experimental Allergy
Issue number1
StatePublished - Jan 1 2016
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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