A Computational, Tissue-Realistic Model of Pressure Ulcer Formation in Individuals with Spinal Cord Injury

Cordelia Ziraldo, Alexey Solovyev, Ana Allegretti, Shilpa Krishnan, M. Kristi Henzel, Gwendolyn A. Sowa, David Brienza, Gary An, Qi Mi, Yoram Vodovotz

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

People with spinal cord injury (SCI) are predisposed to pressure ulcers (PU). PU remain a significant burden in cost of care and quality of life despite improved mechanistic understanding and advanced interventions. An agent-based model (ABM) of ischemia/reperfusion-induced inflammation and PU (the PUABM) was created, calibrated to serial images of post-SCI PU, and used to investigate potential treatments in silico. Tissue-level features of the PUABM recapitulated visual patterns of ulcer formation in individuals with SCI. These morphological features, along with simulated cell counts and mediator concentrations, suggested that the influence of inflammatory dynamics caused simulations to be committed to “better” vs. “worse” outcomes by 4 days of simulated time and prior to ulcer formation. Sensitivity analysis of model parameters suggested that increasing oxygen availability would reduce PU incidence. Using the PUABM, in silico trials of anti-inflammatory treatments such as corticosteroids and a neutralizing antibody targeted at Damage-Associated Molecular Pattern molecules (DAMPs) suggested that, at best, early application at a sufficiently high dose could attenuate local inflammation and reduce pressure-associated tissue damage, but could not reduce PU incidence. The PUABM thus shows promise as an adjunct for mechanistic understanding, diagnosis, and design of therapies in the setting of PU.

Original languageEnglish (US)
Article numbere1004309
JournalPLoS Computational Biology
Volume11
Issue number6
DOIs
StatePublished - Jun 25 2015
Externally publishedYes

Fingerprint

pressure ulcers
Pressure Ulcer
Spinal Cord Injuries
spinal cord
Tissue
Inflammation
angle of incidence
Computer Simulation
Ulcer
Model
inflammation
Incidence
Damage
Reperfusion
damage
Ischemia
adrenal cortex hormones
ischemia
Quality of Life
tissues

ASJC Scopus subject areas

  • Computational Theory and Mathematics
  • Modeling and Simulation
  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Molecular Biology
  • Ecology
  • Cellular and Molecular Neuroscience

Cite this

Ziraldo, C., Solovyev, A., Allegretti, A., Krishnan, S., Henzel, M. K., Sowa, G. A., ... Vodovotz, Y. (2015). A Computational, Tissue-Realistic Model of Pressure Ulcer Formation in Individuals with Spinal Cord Injury. PLoS Computational Biology, 11(6), [e1004309]. https://doi.org/10.1371/journal.pcbi.1004309

A Computational, Tissue-Realistic Model of Pressure Ulcer Formation in Individuals with Spinal Cord Injury. / Ziraldo, Cordelia; Solovyev, Alexey; Allegretti, Ana; Krishnan, Shilpa; Henzel, M. Kristi; Sowa, Gwendolyn A.; Brienza, David; An, Gary; Mi, Qi; Vodovotz, Yoram.

In: PLoS Computational Biology, Vol. 11, No. 6, e1004309, 25.06.2015.

Research output: Contribution to journalArticle

Ziraldo, C, Solovyev, A, Allegretti, A, Krishnan, S, Henzel, MK, Sowa, GA, Brienza, D, An, G, Mi, Q & Vodovotz, Y 2015, 'A Computational, Tissue-Realistic Model of Pressure Ulcer Formation in Individuals with Spinal Cord Injury', PLoS Computational Biology, vol. 11, no. 6, e1004309. https://doi.org/10.1371/journal.pcbi.1004309
Ziraldo, Cordelia ; Solovyev, Alexey ; Allegretti, Ana ; Krishnan, Shilpa ; Henzel, M. Kristi ; Sowa, Gwendolyn A. ; Brienza, David ; An, Gary ; Mi, Qi ; Vodovotz, Yoram. / A Computational, Tissue-Realistic Model of Pressure Ulcer Formation in Individuals with Spinal Cord Injury. In: PLoS Computational Biology. 2015 ; Vol. 11, No. 6.
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