A conserved pocket in the dengue virus polymerase identified through fragment-based screening

Keyphrases

• Polymerase 100%
• Dengue Virus 100%
• Virus Polymerase 100%
• Fragment Screening 100%
• X-ray Crystallography 50%
• RNA-dependent RNA Polymerase (RdRP) 50%
• Related Compounds 50%
• Enzyme Activity 50%
• Rational Design 50%
• Binding Affinity 50%
• High-affinity Binding 50%
• Phenyl 50%
• Isothermal Titration Calorimetry 50%
• Enzyme Inhibition 50%
• Polymerase Activity 50%
• Surface Plasmon Resonance 50%
• Structure-based Design 50%
• Dengue Virus Serotype 3 50%
• Single Hit 50%
• Fragment Screen 50%
• Thiophene 50%
• Rational Structure 50%

Biochemistry, Genetics and Molecular Biology

• Polymerase 100%
• Dengue Virus 100%
• Binding Affinity 50%
• Serotype 50%
• Solution and Solubility 25%
• Enzyme Activity 25%
• RNA-dependent RNA Polymerase 25%
• Isothermal Titration Calorimetry 25%
• Surface Plasmon Resonance 25%
• Thiophene 25%

Pharmacology, Toxicology and Pharmaceutical Science

• Dengue Virus 100%
• RNA Directed RNA Polymerase 33%
• Calorimetry 33%
• Thiophene 33%
• Surface Plasmon Resonance 33%