A convenient procedure for the synthesis of nonsymmetrical bivalent selective serotonin reuptake inhibitors using polymer-supported reagents

Amir P. Tamiz; Paola Conti; Mei Zhang; Kenneth M. Johnson; Alan P. Kozikowski

doi:10.1016/S0960-894X(00)00576-X

A convenient procedure for the synthesis of nonsymmetrical bivalent selective serotonin reuptake inhibitors using polymer-supported reagents

Amir P. Tamiz, Paola Conti, Mei Zhang, Kenneth M. Johnson, Alan P. Kozikowski

Pharmacology & Toxicology

Research output: Contribution to journal › Article

6 Scopus citations

Abstract

A convenient synthesis of nonsymmetrical bivalent inhibitors of the serotonin transporter is described. The synthesis utilizes polymer-supported reagents that allow for rapid access to novel bivalent ligands without the need for isolation or purification of synthetic intermediates. (C) 2000 Elsevier Science Ltd.

Original language	English (US)
Pages (from-to)	2741-2743
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	10
Issue number	24
DOIs	https://doi.org/10.1016/S0960-894X(00)00576-X
State	Published - Dec 18 2000

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ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Cite this

Tamiz, A. P., Conti, P., Zhang, M., Johnson, K. M., & Kozikowski, A. P. (2000). A convenient procedure for the synthesis of nonsymmetrical bivalent selective serotonin reuptake inhibitors using polymer-supported reagents. Bioorganic and Medicinal Chemistry Letters, 10(24), 2741-2743. https://doi.org/10.1016/S0960-894X(00)00576-X

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Access to Document

10.1016/S0960-894X(00)00576-X