A convenient procedure for the synthesis of nonsymmetrical bivalent selective serotonin reuptake inhibitors using polymer-supported reagents

Amir P. Tamiz, Paola Conti, Mei Zhang, Kenneth M. Johnson, Alan P. Kozikowski

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

A convenient synthesis of nonsymmetrical bivalent inhibitors of the serotonin transporter is described. The synthesis utilizes polymer-supported reagents that allow for rapid access to novel bivalent ligands without the need for isolation or purification of synthetic intermediates. (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)2741-2743
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume10
Issue number24
DOIs
StatePublished - Dec 18 2000

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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