A convenient procedure for the synthesis of nonsymmetrical bivalent selective serotonin reuptake inhibitors using polymer-supported reagents

Amir P. Tamiz, Paola Conti, Mei Zhang, Kenneth M. Johnson, Alan P. Kozikowski

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A convenient synthesis of nonsymmetrical bivalent inhibitors of the serotonin transporter is described. The synthesis utilizes polymer-supported reagents that allow for rapid access to novel bivalent ligands without the need for isolation or purification of synthetic intermediates. (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)2741-2743
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume10
Issue number24
StatePublished - Dec 18 2000

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Serotonin Plasma Membrane Transport Proteins
Serotonin Uptake Inhibitors
Polymers
Ligands
Purification

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

A convenient procedure for the synthesis of nonsymmetrical bivalent selective serotonin reuptake inhibitors using polymer-supported reagents. / Tamiz, Amir P.; Conti, Paola; Zhang, Mei; Johnson, Kenneth M.; Kozikowski, Alan P.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 10, No. 24, 18.12.2000, p. 2741-2743.

Research output: Contribution to journalArticle

Tamiz, Amir P. ; Conti, Paola ; Zhang, Mei ; Johnson, Kenneth M. ; Kozikowski, Alan P. / A convenient procedure for the synthesis of nonsymmetrical bivalent selective serotonin reuptake inhibitors using polymer-supported reagents. In: Bioorganic and Medicinal Chemistry Letters. 2000 ; Vol. 10, No. 24. pp. 2741-2743.
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