A critique of clinical equipoise therapeutic misconception in the ethics of clinical trials

Franklin G. Miller, Howard Brody

Research output: Contribution to journalReview article

286 Scopus citations

Abstract

A predominant ethical view holds that physician-investigators should conduct their research with therapeutic intent. And since a physician offering a therapy wouldn't prescribe second-rate treatments, the experimental intervention and the best proven therapy should appear equally effective. "Clinical equipoise" is necessary. But this perspective is flawed. The ethics of research and of therapy are fundamentally different, and clinical equipoise should be abandoned.

Original languageEnglish (US)
Pages (from-to)19-28
Number of pages10
JournalHastings Center Report
Volume33
Issue number3
DOIs
StatePublished - May 1 2003

ASJC Scopus subject areas

  • Health(social science)
  • Issues, ethics and legal aspects
  • Philosophy
  • Health Policy

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