A cross-sectional study of osteocalcin and body fat measures among obese adolescents

Carine M. Lenders, Phillip Lee, Henry A. Feldman, Darrell M. Wilson, Stephanie H. Abrams, Stephen E. Gitelman, William J. Klish, Marcia S. Wertz, George A. Taylor, Richard T. Alongi, Tai C. Chen, Michael F. Holick

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Osteocalcin (OCN), a marker of osteoblast activity, has been implicated in the regulation of energy metabolism by the skeleton and thus may affect body fat measures. Objective: To examine the relationships of OCN to body fat measures and whether they vary according to markers of energy and vitamin D metabolism. Design and Methods: Data were obtained from 58 obese adolescents aged 13-17.9 years (38 females, 8 black or African-American). Total fat mass (FM) [dual X-ray absorptiometry (DXA)] and visceral adipose tissue (VAT) [computerized axial tomography (CT)] were calculated. Blood tests included leptin, OCN, 25-hydroxyvitamin D [25(OH)D], parathyroid hormone (PTH), thyroid function tests, and triglycerides. Markers of glucose metabolism were obtained from fasting and OGTT samples. Results and Conclusions: Adolescents with 25(OH)D <20 ng mL-1 were considered deficient (n = 17/58); none had high PTH (PTH ≥ 65 pg mL-1). OCN was associated with lower VAT (-84.27 ± 33.89 mm2) and BMI (-0.10 ± 0.05 kg m-2), not FM (P = 0.597) in a core model including age, sex, race, geographic latitude, summer, height z-score, and tanner stage. Adding 25(OH)D deficiency and PTH attenuated the inverse association of OCN to VAT. There was a significant interaction of OCN and 25(OH)D deficiency on FM (0.37 ± 0.18 kg, P = 0.041) and BMI (0.28 ± 0.10 kg m-2, P = 0.007) in this adjusted model, which was further explained by leptin. Adding A1C to the core model modified the relationship of OCN to VAT (-93.08 ± 35.05 mm 2, P = 0.011), which was further explained by HOMA-IR. In summary, these findings provide initial evidence for a relationship between OCN and body fat measures that is dependent on energy metabolism and vitamin D status among obese adolescents.

Original languageEnglish (US)
Pages (from-to)808-814
Number of pages7
JournalObesity
Volume21
Issue number4
DOIs
StatePublished - Apr 2013
Externally publishedYes

Fingerprint

Body Weights and Measures
Osteocalcin
Adipose Tissue
Cross-Sectional Studies
Intra-Abdominal Fat
Parathyroid Hormone
Fats
Leptin
Vitamin D
Energy Metabolism
Thyroid Function Tests
Photon Absorptiometry
Hematologic Tests
Glucose Tolerance Test
Osteoblasts
Skeleton
African Americans
Fasting
Triglycerides
Tomography

ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Lenders, C. M., Lee, P., Feldman, H. A., Wilson, D. M., Abrams, S. H., Gitelman, S. E., ... Holick, M. F. (2013). A cross-sectional study of osteocalcin and body fat measures among obese adolescents. Obesity, 21(4), 808-814. https://doi.org/10.1002/oby.20131

A cross-sectional study of osteocalcin and body fat measures among obese adolescents. / Lenders, Carine M.; Lee, Phillip; Feldman, Henry A.; Wilson, Darrell M.; Abrams, Stephanie H.; Gitelman, Stephen E.; Klish, William J.; Wertz, Marcia S.; Taylor, George A.; Alongi, Richard T.; Chen, Tai C.; Holick, Michael F.

In: Obesity, Vol. 21, No. 4, 04.2013, p. 808-814.

Research output: Contribution to journalArticle

Lenders, CM, Lee, P, Feldman, HA, Wilson, DM, Abrams, SH, Gitelman, SE, Klish, WJ, Wertz, MS, Taylor, GA, Alongi, RT, Chen, TC & Holick, MF 2013, 'A cross-sectional study of osteocalcin and body fat measures among obese adolescents', Obesity, vol. 21, no. 4, pp. 808-814. https://doi.org/10.1002/oby.20131
Lenders CM, Lee P, Feldman HA, Wilson DM, Abrams SH, Gitelman SE et al. A cross-sectional study of osteocalcin and body fat measures among obese adolescents. Obesity. 2013 Apr;21(4):808-814. https://doi.org/10.1002/oby.20131
Lenders, Carine M. ; Lee, Phillip ; Feldman, Henry A. ; Wilson, Darrell M. ; Abrams, Stephanie H. ; Gitelman, Stephen E. ; Klish, William J. ; Wertz, Marcia S. ; Taylor, George A. ; Alongi, Richard T. ; Chen, Tai C. ; Holick, Michael F. / A cross-sectional study of osteocalcin and body fat measures among obese adolescents. In: Obesity. 2013 ; Vol. 21, No. 4. pp. 808-814.
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