@article{926cc866785840bc9eab78daec00240e,
title = "A Cytogenetic Profile of Radiation Damage",
abstract = "Most of the important biological effects associated with the exposure to ionizing radiations are mirrored at the chromosomal level. In all cases, changes in the levels of cytogenetic effects are associated with changes in absorbed dose, dose rate and radiation quality. Some of the complexities associated with the quantitative description of such changes in response can be circumvented by appealing to concepts embodied in what has been called the {"}mean inactivation dose{"}. Additional metrics designed to provide LET-dependent {"}signatures{"} of damage have been employed with moderate degrees of success. These, along with some alternative approaches, are discussed in an effort to stimulate discussion, and to further work leading to a better understanding of mechanisms involved in the production and significance of chromosome aberrations after exposure to ionizing radiations.",
author = "Cornforth, {Michael N.} and Loucas, {Bradford D.}",
note = "Funding Information: We are indebted to the following people without whom the substance of this paper would be diminished: Dudley Goodhead, for his valued input over the years via many discussions involving virtually all aspects of radiation effects; and Igor Shuryak, for stimulating discussions regarding overdispersion, and for propagating statistical errors associated with Fig. 4. This work was supported by the National Aeronautics and Space Administration (NASA grant nos. NNX15AG74G to MC and 80NSSC18K0864 to BL). Earlier support from the National Institutes of Health is also gratefully acknowledged (grant no. R01080486-02 to MC). The authors dedicate this manuscript to three exceptional scientists: Joel Bedford for his steadfast support and decades-long mentorship, and to both John Savage and Rainer Sachs, whose enthusiasm and collective body of work stands as proof that there remains elegance in the biophysical approach to radiation biology. Publisher Copyright: {\textcopyright} 2019 by Radiation Research Society. All rights of reproduction in any form reserved.",
year = "2019",
month = jan,
day = "1",
doi = "10.1667/RR15205.1",
language = "English (US)",
volume = "191",
pages = "1--19",
journal = "Radiation research",
issn = "0033-7587",
publisher = "Radiation Research Society",
number = "1",
}