A defect-in-continuity in the canine femur: And in-vivo experimental model for the study of bone graft incorporation

R. W. Lindsey, T. Miclau, R. Probe, S. Perren

Research output: Contribution to journalArticle

9 Scopus citations


The in-vivo study of bone graft incorporation has traditionally used a segmental diaphyseal bone defect. This model reliably produces a nonunion, but is complicated by graft instability and altered limb loading stresses. The authors discuss the advantages of a defect-in-continuity canine femur model which produces a more consistent union with fewer mechanical complications despite the absence of fixation. This proposed model permits analysis of radiographic, histologic and biomechanical data which are more applicable to the usual clinical setting in which bone graft is required.

Original languageEnglish (US)
Pages (from-to)157-163
Number of pages7
JournalYale Journal of Biology and Medicine
Issue number3
StatePublished - Jan 1 1994
Externally publishedYes


ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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