A description of the methods of the Nulliparous Pregnancy Outcomes Study: Monitoring mothers-to-be (nuMoM2b)

David M. Haas, Corette B. Parker, Deborah A. Wing, Samuel Parry, William A. Grobman, Brian M. Mercer, Hyagriv N. Simhan, Matthew K. Hoffman, Robert M. Silver, Pathik Wadhwa, Jay D. Iams, Matthew A. Koch, Steve N. Caritis, Ronald J. Wapner, M. Sean Esplin, Michal A. Elovitz, Tatiana Foroud, Alan M. Peaceman, George R. Saade, Marian WillingerUma M. Reddy

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

Objective The primary aim of the "Nulliparous Pregnancy Outcomes Study: monitoring mothers-to-be" is to determine maternal characteristics, which include genetic, physiologic response to pregnancy, and environmental factors that predict adverse pregnancy outcomes. Study Design Nulliparous women in the first trimester of pregnancy were recruited into an observational cohort study. Participants were seen at 3 study visits during pregnancy and again at delivery. We collected data from in-clinic interviews, take-home surveys, clinical measurements, ultrasound studies, and chart abstractions. Maternal biospecimens (serum, plasma, urine, cervicovaginal fluid) at antepartum study visits and delivery specimens (placenta, umbilical cord, cord blood) were collected, processed, and stored. The primary outcome of the study was defined as pregnancy ending at <37+0 weeks' gestation. Key study hypotheses involve adverse pregnancy outcomes of spontaneous preterm birth, preeclampsia, and fetal growth restriction. Results We recruited 10,037 women to the study. Basic characteristics of the cohort at screening are reported. Conclusion The "Nulliparous Pregnancy Outcomes Study: monitoring mothers-to-be" cohort study methods and procedures can help investigators when they plan future projects.

Original languageEnglish (US)
Pages (from-to)539.e1-539.e24
JournalAmerican journal of obstetrics and gynecology
Volume212
Issue number4
DOIs
StatePublished - Apr 1 2015

Keywords

  • adverse pregnancy outcome
  • cohort study
  • methods
  • nulliparous
  • prediction
  • pregnancy
  • psychosocial

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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    Haas, D. M., Parker, C. B., Wing, D. A., Parry, S., Grobman, W. A., Mercer, B. M., Simhan, H. N., Hoffman, M. K., Silver, R. M., Wadhwa, P., Iams, J. D., Koch, M. A., Caritis, S. N., Wapner, R. J., Esplin, M. S., Elovitz, M. A., Foroud, T., Peaceman, A. M., Saade, G. R., ... Reddy, U. M. (2015). A description of the methods of the Nulliparous Pregnancy Outcomes Study: Monitoring mothers-to-be (nuMoM2b). American journal of obstetrics and gynecology, 212(4), 539.e1-539.e24. https://doi.org/10.1016/j.ajog.2015.01.019