A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota

Yingzi Cong, Ting Feng, Kohtaro Fujihashi, Trenton R. Schoeb, Charles O. Elson

Research output: Contribution to journalArticle

235 Citations (Scopus)

Abstract

A T cell receptor transgenic mouse line reactive to a microbiota flagellin, CBir1, was used to define mechanisms of host microbiota homeostasis. Intestinal IgA, but not serum IgA, was found to block mucosal flagellin uptake and systemic T cell activation in mice. Depletion of CD4+CD25+ Tregs decreased IgA+ B cells, total IgA, and CBir1-specific IgA in gut within days. Repletion of T cell-deficient mice with either CD4 +CD25+ or CD4+foxp3+ Tregs restored intestinal IgA to a much greater extent than their reciprocal CD4+ subsets, indicating that Tregs are the major helper cells for IgA responses to microbiota antigens such as flagellin. We propose that the major role of this coordinated Treg-IgA response is to maintain commensalism with the microbiota.

Original languageEnglish (US)
Pages (from-to)19256-19261
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume106
Issue number46
DOIs
StatePublished - Nov 17 2009
Externally publishedYes

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Regulatory T-Lymphocytes
Immunoglobulin A
Microbiota
Flagellin
T-Lymphocytes
Symbiosis
Gastrointestinal Microbiome
Helper-Inducer T-Lymphocytes
T-Cell Antigen Receptor
Transgenic Mice
Homeostasis
B-Lymphocytes
Antigens
Serum

Keywords

  • T cells
  • TGF-beta
  • Tregs

ASJC Scopus subject areas

  • General

Cite this

A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota. / Cong, Yingzi; Feng, Ting; Fujihashi, Kohtaro; Schoeb, Trenton R.; Elson, Charles O.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, No. 46, 17.11.2009, p. 19256-19261.

Research output: Contribution to journalArticle

Cong, Yingzi ; Feng, Ting ; Fujihashi, Kohtaro ; Schoeb, Trenton R. ; Elson, Charles O. / A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota. In: Proceedings of the National Academy of Sciences of the United States of America. 2009 ; Vol. 106, No. 46. pp. 19256-19261.
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