A double-blind, placebo-controlled trial of decongestant-antihistamine for the treatment of sinusitis in children

David P. McCormick, Susan D. John, Leonard E. Swischuk, Tatsuo Uchida

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

We studied the effectiveness of nasal decongestant-antihistamine in treating acute sinusitis in children. All subjects received oral amoxicillin for 14 days. Subjects randomized to the decongestant-antihistamine group received nasal oxymetazolone and oral syrup containing brompheniramine and phenylpropanolamine. Controls received placebo nasal saline and oral syrup. In both groups symptoms resolved quickly, and radiographs improved significantly. Responses to treatment were similar between the two groups. Water's radiographs of the maxillary sinuses proved reliable in the assessment of the degree of sinus involvement. We conclude that decongestant- antihistamine need not be given to the child with acute maxillary sinusitis.

Original languageEnglish (US)
Pages (from-to)457-460
Number of pages4
JournalClinical Pediatrics
Volume35
Issue number9
StatePublished - Sep 1996

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Nasal Decongestants
Histamine Antagonists
Sinusitis
Placebos
Nose
Brompheniramine
Phenylpropanolamine
Maxillary Sinusitis
Maxillary Sinus
Amoxicillin
Therapeutics
Water

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

McCormick, D. P., John, S. D., Swischuk, L. E., & Uchida, T. (1996). A double-blind, placebo-controlled trial of decongestant-antihistamine for the treatment of sinusitis in children. Clinical Pediatrics, 35(9), 457-460.

A double-blind, placebo-controlled trial of decongestant-antihistamine for the treatment of sinusitis in children. / McCormick, David P.; John, Susan D.; Swischuk, Leonard E.; Uchida, Tatsuo.

In: Clinical Pediatrics, Vol. 35, No. 9, 09.1996, p. 457-460.

Research output: Contribution to journalArticle

McCormick, DP, John, SD, Swischuk, LE & Uchida, T 1996, 'A double-blind, placebo-controlled trial of decongestant-antihistamine for the treatment of sinusitis in children', Clinical Pediatrics, vol. 35, no. 9, pp. 457-460.
McCormick, David P. ; John, Susan D. ; Swischuk, Leonard E. ; Uchida, Tatsuo. / A double-blind, placebo-controlled trial of decongestant-antihistamine for the treatment of sinusitis in children. In: Clinical Pediatrics. 1996 ; Vol. 35, No. 9. pp. 457-460.
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