A double-blind, placebo-controlled trial of decongestant-antihistamine for the treatment of sinusitis in children

David P. McCormick; Susan D. John; Leonard E. Swischuk; Tatsuo Uchida

doi:10.1177/000992289603500905

A double-blind, placebo-controlled trial of decongestant-antihistamine for the treatment of sinusitis in children

David P. McCormick, Susan D. John, Leonard E. Swischuk, Tatsuo Uchida

Research output: Contribution to journal › Article › peer-review

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Abstract

We studied the effectiveness of nasal decongestant-antihistamine in treating acute sinusitis in children. All subjects received oral amoxicillin for 14 days. Subjects randomized to the decongestant-antihistamine group received nasal oxymetazolone and oral syrup containing brompheniramine and phenylpropanolamine. Controls received placebo nasal saline and oral syrup. In both groups symptoms resolved quickly, and radiographs improved significantly. Responses to treatment were similar between the two groups. Water's radiographs of the maxillary sinuses proved reliable in the assessment of the degree of sinus involvement. We conclude that decongestant- antihistamine need not be given to the child with acute maxillary sinusitis.

Original language	English (US)
Pages (from-to)	457-460
Number of pages	4
Journal	Clinical pediatrics
Volume	35
Issue number	9
DOIs	https://doi.org/10.1177/000992289603500905
State	Published - Sep 1996

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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abstract = "We studied the effectiveness of nasal decongestant-antihistamine in treating acute sinusitis in children. All subjects received oral amoxicillin for 14 days. Subjects randomized to the decongestant-antihistamine group received nasal oxymetazolone and oral syrup containing brompheniramine and phenylpropanolamine. Controls received placebo nasal saline and oral syrup. In both groups symptoms resolved quickly, and radiographs improved significantly. Responses to treatment were similar between the two groups. Water's radiographs of the maxillary sinuses proved reliable in the assessment of the degree of sinus involvement. We conclude that decongestant- antihistamine need not be given to the child with acute maxillary sinusitis.",

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A double-blind, placebo-controlled trial of decongestant-antihistamine for the treatment of sinusitis in children

Abstract

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