A functional genetic approach suggests a novel interaction between the human immunodeficiency virus type 1 (HIV-1) Tat protein and HIV-1 TAR RNA in vivo

Lars H. Lund, Britta Wahren, Mariano A. Garcia-Blanco

Research output: Contribution to journalArticle

8 Scopus citations


Human immunodeficiency virus type 1 (HIV-1) Tat and human Cyclin T1 form a complex and together recognize the viral TAR RNA element with specificity. Using HIV-1/equine infectious anaemia virus TAR chimeras, we show that in addition to the well-characterized interaction with the bulge, Tat recognizes the distal stem and the loop of TAR. These data support previously proposed, but unproven, molecular models.

Original languageEnglish (US)
Pages (from-to)603-606
Number of pages4
JournalJournal of General Virology
Issue number3
StatePublished - Mar 1 2003
Externally publishedYes


ASJC Scopus subject areas

  • Virology

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