A functional genetic approach suggests a novel interaction between the human immunodeficiency virus type 1 (HIV-1) Tat protein and HIV-1 TAR RNA in vivo

Lars H. Lund, Britta Wahren, Mariano Garcia-Blanco

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Human immunodeficiency virus type 1 (HIV-1) Tat and human Cyclin T1 form a complex and together recognize the viral TAR RNA element with specificity. Using HIV-1/equine infectious anaemia virus TAR chimeras, we show that in addition to the well-characterized interaction with the bulge, Tat recognizes the distal stem and the loop of TAR. These data support previously proposed, but unproven, molecular models.

Original languageEnglish (US)
Pages (from-to)603-606
Number of pages4
JournalJournal of General Virology
Volume84
Issue number3
DOIs
StatePublished - Mar 1 2003
Externally publishedYes

Fingerprint

tat Gene Products
HIV-1
Cyclin T
Equine infectious anemia virus
RNA
Molecular Models
Viral RNA

ASJC Scopus subject areas

  • Virology
  • Immunology

Cite this

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