TY - JOUR
T1 - A functional genetic approach suggests a novel interaction between the human immunodeficiency virus type 1 (HIV-1) Tat protein and HIV-1 TAR RNA in vivo
AU - Lund, Lars H.
AU - Wahren, Britta
AU - Garcia-Blanco, Mariano A.
PY - 2003/3/1
Y1 - 2003/3/1
N2 - Human immunodeficiency virus type 1 (HIV-1) Tat and human Cyclin T1 form a complex and together recognize the viral TAR RNA element with specificity. Using HIV-1/equine infectious anaemia virus TAR chimeras, we show that in addition to the well-characterized interaction with the bulge, Tat recognizes the distal stem and the loop of TAR. These data support previously proposed, but unproven, molecular models.
AB - Human immunodeficiency virus type 1 (HIV-1) Tat and human Cyclin T1 form a complex and together recognize the viral TAR RNA element with specificity. Using HIV-1/equine infectious anaemia virus TAR chimeras, we show that in addition to the well-characterized interaction with the bulge, Tat recognizes the distal stem and the loop of TAR. These data support previously proposed, but unproven, molecular models.
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U2 - 10.1099/vir.0.18645-0
DO - 10.1099/vir.0.18645-0
M3 - Article
C2 - 12604811
AN - SCOPUS:0037373493
SN - 0022-1317
VL - 84
SP - 603
EP - 606
JO - Journal of General Virology
JF - Journal of General Virology
IS - 3
ER -