Abstract
Human immunodeficiency virus type 1 (HIV-1) Tat and human Cyclin T1 form a complex and together recognize the viral TAR RNA element with specificity. Using HIV-1/equine infectious anaemia virus TAR chimeras, we show that in addition to the well-characterized interaction with the bulge, Tat recognizes the distal stem and the loop of TAR. These data support previously proposed, but unproven, molecular models.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 603-606 |
| Number of pages | 4 |
| Journal | Journal of General Virology |
| Volume | 84 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1 2003 |
| Externally published | Yes |
ASJC Scopus subject areas
- Virology
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