A high repetition rate (1 kHz) microcrystal laser for high throughput atmospheric pressure MALDI-quadrupole-time-of-flight mass spectrometry

John A. McLean, William Russell, David H. Russell

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Sample throughput has been increased in many areas of proteomics, but the last significant advance in lasers used for matrix-assisted laser desorption/ionization (MALDI) was the introduction of cartridge-type N 2 lasers (337 nm, 4-ns pulse widths, 1-30-Hz repetition rates) more than a decade ago. This report describes the application of a 1-kHz repetition rate Nd:YAG laser (355 nm,

Original languageEnglish (US)
Pages (from-to)648-654
Number of pages7
JournalAnalytical Chemistry
Volume75
Issue number3
DOIs
StatePublished - Feb 1 2003
Externally publishedYes

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Microcrystals
Atmospheric pressure
Ionization
Mass spectrometry
Desorption
Throughput
Lasers
Laser pulses

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

A high repetition rate (1 kHz) microcrystal laser for high throughput atmospheric pressure MALDI-quadrupole-time-of-flight mass spectrometry. / McLean, John A.; Russell, William; Russell, David H.

In: Analytical Chemistry, Vol. 75, No. 3, 01.02.2003, p. 648-654.

Research output: Contribution to journalArticle

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