Abstract
A Lewis acid promoted highly diastereoselective asymmetric Friedel-Crafts alkylation of indoles with isatin-derived N-tert-butanesulfinyl ketimines is described. The reaction can be accomplished with ease in the presence of a catalytic amount of Bi(OTf)3, providing a series of 3-indolyl-3-aminooxindoles in excellent diastereoselectivities (up to 98% de) and yields (up to 99%).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3363-3370 |
| Number of pages | 8 |
| Journal | Organic and Biomolecular Chemistry |
| Volume | 13 |
| Issue number | 11 |
| DOIs | |
| State | Published - 2015 |
| Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
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