A histone acetyltransferase regulates active DNA demethylation in Arabidopsis

Weiqiang Qian, Daisuke Miki, Heng Zhang, Yunhua Liu, Xi Zhang, Kai Tang, Yunchao Kan, Honggui La, Xiaojie Li, Shaofang Li, Xiaohong Zhu, Xiaobing Shi, Kangling Zhang, Olga Pontes, Xuemei Chen, Renyi Liu, Zhizhong Gong, Jian Kang Zhu

Research output: Contribution to journalArticle

115 Citations (Scopus)

Abstract

Active DNA demethylation is an important part of epigenetic regulation in plants and animals. How active DNA demethylation is regulated and its relationship with histone modification patterns are unclear. Here, we report the discovery of IDM1, a regulator of DNA demethylation in Arabidopsis. IDM1 is required for preventing DNA hypermethylation of highly homologous multicopy genes and other repetitive sequences that are normally targeted for active DNA demethylation by Repressor of Silencing 1 and related 5-methylcytosine DNA glycosylases. IDM1 binds methylated DNA at chromatin sites lacking histone H3K4 di- or trimethylation and acetylates H3 to create a chromatin environment permissible for 5-methylcytosine DNA glycosylases to function. Our study reveals how some genes are indicated by multiple epigenetic marks for active DNA demethylation and protection from silencing.

Original languageEnglish (US)
Pages (from-to)1445-1448
Number of pages4
JournalScience
Volume336
Issue number6087
DOIs
StatePublished - Jun 15 2012
Externally publishedYes

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Histone Acetyltransferases
Arabidopsis
DNA
Epigenomics
Chromatin
Histone Code
Nucleic Acid Repetitive Sequences
Histones
Genes

ASJC Scopus subject areas

  • General

Cite this

Qian, W., Miki, D., Zhang, H., Liu, Y., Zhang, X., Tang, K., ... Zhu, J. K. (2012). A histone acetyltransferase regulates active DNA demethylation in Arabidopsis. Science, 336(6087), 1445-1448. https://doi.org/10.1126/science.1219416

A histone acetyltransferase regulates active DNA demethylation in Arabidopsis. / Qian, Weiqiang; Miki, Daisuke; Zhang, Heng; Liu, Yunhua; Zhang, Xi; Tang, Kai; Kan, Yunchao; La, Honggui; Li, Xiaojie; Li, Shaofang; Zhu, Xiaohong; Shi, Xiaobing; Zhang, Kangling; Pontes, Olga; Chen, Xuemei; Liu, Renyi; Gong, Zhizhong; Zhu, Jian Kang.

In: Science, Vol. 336, No. 6087, 15.06.2012, p. 1445-1448.

Research output: Contribution to journalArticle

Qian, W, Miki, D, Zhang, H, Liu, Y, Zhang, X, Tang, K, Kan, Y, La, H, Li, X, Li, S, Zhu, X, Shi, X, Zhang, K, Pontes, O, Chen, X, Liu, R, Gong, Z & Zhu, JK 2012, 'A histone acetyltransferase regulates active DNA demethylation in Arabidopsis', Science, vol. 336, no. 6087, pp. 1445-1448. https://doi.org/10.1126/science.1219416
Qian W, Miki D, Zhang H, Liu Y, Zhang X, Tang K et al. A histone acetyltransferase regulates active DNA demethylation in Arabidopsis. Science. 2012 Jun 15;336(6087):1445-1448. https://doi.org/10.1126/science.1219416
Qian, Weiqiang ; Miki, Daisuke ; Zhang, Heng ; Liu, Yunhua ; Zhang, Xi ; Tang, Kai ; Kan, Yunchao ; La, Honggui ; Li, Xiaojie ; Li, Shaofang ; Zhu, Xiaohong ; Shi, Xiaobing ; Zhang, Kangling ; Pontes, Olga ; Chen, Xuemei ; Liu, Renyi ; Gong, Zhizhong ; Zhu, Jian Kang. / A histone acetyltransferase regulates active DNA demethylation in Arabidopsis. In: Science. 2012 ; Vol. 336, No. 6087. pp. 1445-1448.
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