A Lethal Aerosol Exposure Model of Nipah Virus Strain Bangladesh in African Green Monkeys

Abhishek N. Prasad; Krystle N. Agans; Satheesh K. Sivasubramani; Joan B. Geisbert; Viktoriya Borisevich; Chad E. Mire; William S. Lawrence; Karla A. Fenton; Thomas W. Geisbert

doi:10.1093/infdis/jiz469

A Lethal Aerosol Exposure Model of Nipah Virus Strain Bangladesh in African Green Monkeys

Abhishek N. Prasad, Krystle N. Agans, Satheesh K. Sivasubramani, Joan B. Geisbert, Viktoriya Borisevich, Chad E. Mire, William S. Lawrence, Karla A. Fenton, Thomas W. Geisbert

Microbiology And Immunology

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The high case-fatality rates and potential for use as a biological weapon make Nipah virus (NiV) a significant public health concern. Previous studies assessing the pathogenic potential of NiV delivered by the aerosol route in African green monkeys (AGMs) used the Malaysia strain (NiV_M), which has caused lower instances of respiratory illness and person-to-person transmission during human outbreaks than the Bangladesh strain (NiV_B). Accordingly, we developed a small particle aerosol model of NiV_B infection in AGMs. Consistent with other mucosal AGM models of NiV_B infection, we achieved uniform lethality and disease pathogenesis reflective of that observed in humans.

Original language	English (US)
Pages (from-to)	S431-S435
Journal	Journal of Infectious Diseases
Volume	221
DOIs	https://doi.org/10.1093/infdis/jiz469
State	Published - May 11 2020

Keywords

Nipah virus
aerosol
animal model
pathogenesis
primate

ASJC Scopus subject areas

General Medicine

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10.1093/infdis/jiz469

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title = "A Lethal Aerosol Exposure Model of Nipah Virus Strain Bangladesh in African Green Monkeys",

abstract = "The high case-fatality rates and potential for use as a biological weapon make Nipah virus (NiV) a significant public health concern. Previous studies assessing the pathogenic potential of NiV delivered by the aerosol route in African green monkeys (AGMs) used the Malaysia strain (NiVM), which has caused lower instances of respiratory illness and person-to-person transmission during human outbreaks than the Bangladesh strain (NiVB). Accordingly, we developed a small particle aerosol model of NiVB infection in AGMs. Consistent with other mucosal AGM models of NiVB infection, we achieved uniform lethality and disease pathogenesis reflective of that observed in humans.",

keywords = "Nipah virus, aerosol, animal model, pathogenesis, primate",

author = "Prasad, {Abhishek N.} and Agans, {Krystle N.} and Sivasubramani, {Satheesh K.} and Geisbert, {Joan B.} and Viktoriya Borisevich and Mire, {Chad E.} and Lawrence, {William S.} and Fenton, {Karla A.} and Geisbert, {Thomas W.}",

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doi = "10.1093/infdis/jiz469",

language = "English (US)",

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AU - Prasad, Abhishek N.

AU - Agans, Krystle N.

AU - Sivasubramani, Satheesh K.

AU - Geisbert, Joan B.

AU - Borisevich, Viktoriya

AU - Mire, Chad E.

AU - Lawrence, William S.

AU - Fenton, Karla A.

AU - Geisbert, Thomas W.

N1 - Publisher Copyright: © 2019 The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected].

PY - 2020/5/11

Y1 - 2020/5/11

N2 - The high case-fatality rates and potential for use as a biological weapon make Nipah virus (NiV) a significant public health concern. Previous studies assessing the pathogenic potential of NiV delivered by the aerosol route in African green monkeys (AGMs) used the Malaysia strain (NiVM), which has caused lower instances of respiratory illness and person-to-person transmission during human outbreaks than the Bangladesh strain (NiVB). Accordingly, we developed a small particle aerosol model of NiVB infection in AGMs. Consistent with other mucosal AGM models of NiVB infection, we achieved uniform lethality and disease pathogenesis reflective of that observed in humans.

AB - The high case-fatality rates and potential for use as a biological weapon make Nipah virus (NiV) a significant public health concern. Previous studies assessing the pathogenic potential of NiV delivered by the aerosol route in African green monkeys (AGMs) used the Malaysia strain (NiVM), which has caused lower instances of respiratory illness and person-to-person transmission during human outbreaks than the Bangladesh strain (NiVB). Accordingly, we developed a small particle aerosol model of NiVB infection in AGMs. Consistent with other mucosal AGM models of NiVB infection, we achieved uniform lethality and disease pathogenesis reflective of that observed in humans.

KW - Nipah virus

KW - aerosol

KW - animal model

KW - pathogenesis

KW - primate

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VL - 221

SP - S431-S435

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

ER -

A Lethal Aerosol Exposure Model of Nipah Virus Strain Bangladesh in African Green Monkeys

Abstract

Keywords

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