A lethal murine infection model for dengue virus 3 in AG129 mice deficient in type I and II interferon receptors leads to systemic disease

Keyphrases

• Type I Interferon 100%
• Murine Model 100%
• Interferon Receptor 100%
• Mouse-adapted 100%
• Dengue Virus Type 3 100%
• Systemic Disease 100%
• AG129 Mice 100%
• Type II Interferon 100%
• DENV-1 66%
• Human Isolates 66%
• DENV-3 66%
• Virus 33%
• Illness 33%
• Receptor Signaling 33%
• Vaccine Antigen 33%
• Acute Disease 33%
• Human Disease 33%
• Liver 33%
• Small Animal Model 33%
• Inoculation 33%
• Neurovirulence 33%
• Dengue 33%
• Spleen 33%
• Lethal Infection 33%
• Vascular Leakage 33%
• Liver Tissue 33%
• Interferon-α (IFN-α) 33%
• Fatal Infection 33%
• Large Intestine 33%
• Infection Model 33%
• Histological Changes 33%
• Leukopenia 33%
• Thrombocytopenia 33%
• DENV-2 33%
• Beta-gamma 33%
• Thai 33%
• Homotypic 33%
• Physical Signs 33%
• High Viral Load 33%
• Old Animals 33%
• Disease-based 33%
• DENV-4 33%
• Spleen Tissue 33%
• Acute Outcome 33%
• Mosquito-borne Diseases 33%
• Dengue Disease 33%
• Serum Cytokine Level 33%
• Dengue Pathogenesis 33%
• Neurotropic Disease 33%

Immunology and Microbiology

• Interferon Gamma 100%
• Dengue Virus 3 100%
• Infection 100%
• Dengue Fever 50%
• Dengue Virus 50%
• Dengue Virus 1 33%
• Cytokine 16%
• Viral Load 16%
• Interferon Alfa 16%
• Large Intestine 16%
• Spleen Tissue 16%
• Dengue Virus 4 16%
• Liver Tissue 16%
• Dengue Virus 2 16%
• Interferon-Gamma Receptor 16%
• Virus 16%