A light and electron microscopic level analysis of calcitonin gene-related peptide (CGRP) in the spinal cord of the primate: An immunohistochemical study

S. M. Carlton, D. L. McNeill, K. Chung, R. E. Coggeshall

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In the present study, the distribution of calcitonin gene-related peptide (CGRP)-stained fibers and varicosities are demonstrated in the lumbar spinal cord of the monkey at the light microscopic level. Immunostained fibers and varicosities form a dense plexus in laminae I, IIo, the reticulated region of lamina V, and in the region of the central canal. The intervaricose fibers consistently measured 1 μm or less in diameter suggesting a population of finely myelinated or unmyelinated fibers. At the electron microscopic level, two types of terminals were labeled: a glomerular type where one CGRP-labeled profile was indented by several unlabeled postsynaptic profiles and an axodendritic type with one or sometimes two postsynaptic elements. The most noteworthy cytologic feature of CGRP-labeled profiles was the presence of many relatively large vesicles with dense cores. These findings are steps towards understanding the synaptic interactions of CGRP in the monkey dorsal horn.

Original languageEnglish (US)
Pages (from-to)145-150
Number of pages6
JournalNeuroscience Letters
Issue number2
StatePublished - Nov 23 1987



  • Lumbar cord
  • Monkey
  • Primary afferent
  • Ultrastructure

ASJC Scopus subject areas

  • Neuroscience(all)

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