A lipogenic effect in intact male hamsters infected with plerocercoids of the tapeworm, Spirometra mansonoides.

C. K. Phares, Richard Carroll

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Plerocercoids of the tapeworm, Spirometra mansonoides, produce a potent growth stimulating substance which is active in several species of mammals. While most of the actions of the plerocercoid growth factor (PGF) are similar to those of growth hormone (GH), lipid metabolism is one area where their actions are not alike. This report demonstrates that plerocercoid infection not only stimulates growth of intact male hamsters but is lipogenic as well. The lipogenic effects of plerocercoid infection were demonstrated by increases in epididymal fat pad weights, serum triglycerides, cholesterol, and total lipid. The livers of the plerocercoid-infected hamsters also had more cholesterol and more lipid phosphorus than controls. Incorporation studies using [2-14C]acetate showed that infected hamsters incorporated significantly higher levels of the radionuclide in their livers and serum after 1 hr than the controls. The lipogenic effect of plerocercoid infection is distinctly unlike the reported lipolytic action of GH and the lack of any stimulation of [2-14C]acetate incorporation into the epididymal fat pads is unlike the reported acute actions of insulin as well.

Original languageEnglish (US)
Pages (from-to)690-693
Number of pages4
JournalJournal of Parasitology
Volume63
Issue number4
StatePublished - Aug 1977
Externally publishedYes

Fingerprint

Spirometra mansonoides
Spirometra
plerocercoids
Cestoda
tapeworms
hamsters
Cricetinae
Growth Hormone
Adipose Tissue
Acetates
Infection
Cholesterol
Growth Substances
lipid
Lipids
Liver
fat
hormone
lipids
serum

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Microbiology
  • Parasitology

Cite this

A lipogenic effect in intact male hamsters infected with plerocercoids of the tapeworm, Spirometra mansonoides. / Phares, C. K.; Carroll, Richard.

In: Journal of Parasitology, Vol. 63, No. 4, 08.1977, p. 690-693.

Research output: Contribution to journalArticle

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