A longitudinal study of hantavirus infection in three sympatric reservoir species in agroecosystems on the Argentine Pampa

James N. Mills, Karina Schmidt, Barbara A. Ellis, Gladys Calderón, Delia A. Enría, Thomas Ksiazek

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Prevalence of antibody reactive with Sin Nombre hantavirus (SNV) was evaluated from rodents captured over 31 months (March 1988 to September 1990) from six mark-recapture grids on the central Argentine Pampa. The most frequently infected rodents were: Akodon azarae (31/459), Necromys benefactus (8/141), and Oligoryzomys flavescens (10/281), which are known hosts of Pergamino, Maciel, and Lechiguanas hantaviruses, respectively. Relative population density and antibody prevalence varied seasonally and from year to year, population densities were highest in fall and prevalences were highest in spring. A positive association between antibody prevalence and body weight corroborated findings from other studies suggesting that hantaviruses are maintained in reservoir populations by horizontal transmission. In two of three host species, transmission was more frequent among male than among female mice. We found no evidence for a detrimental effect of hantavirus infection on host body weight, growth, longevity, movement, or reproductive preparedness. This analysis, based on cryopreserved specimens, represents the earliest conducted longitudinal, mark-recapture study of the dynamics of infection of autochthonous American hantaviruses in their sigmodontine host populations.

Original languageEnglish (US)
Pages (from-to)229-240
Number of pages12
JournalVector-Borne and Zoonotic Diseases
Volume7
Issue number2
DOIs
StatePublished - Jun 2007
Externally publishedYes

Fingerprint

Hantavirus Infections
Sympatry
Hantavirus
Longitudinal Studies
Population Density
Antibodies
Rodentia
Body Weight
Specific Gravity
Population
Growth
Infection

Keywords

  • Akodon azarae
  • Argentina
  • Hantavirus
  • Host ecology
  • Lechiguanas virus
  • Maciel virus
  • Necromys benefactus
  • Oligoryzomys flavescens
  • Pergamino virus

ASJC Scopus subject areas

  • Infectious Diseases
  • Parasitology

Cite this

A longitudinal study of hantavirus infection in three sympatric reservoir species in agroecosystems on the Argentine Pampa. / Mills, James N.; Schmidt, Karina; Ellis, Barbara A.; Calderón, Gladys; Enría, Delia A.; Ksiazek, Thomas.

In: Vector-Borne and Zoonotic Diseases, Vol. 7, No. 2, 06.2007, p. 229-240.

Research output: Contribution to journalArticle

Mills, James N. ; Schmidt, Karina ; Ellis, Barbara A. ; Calderón, Gladys ; Enría, Delia A. ; Ksiazek, Thomas. / A longitudinal study of hantavirus infection in three sympatric reservoir species in agroecosystems on the Argentine Pampa. In: Vector-Borne and Zoonotic Diseases. 2007 ; Vol. 7, No. 2. pp. 229-240.
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