Brûlure grave chez une transplantée hépatique

Translated title of the contribution: A major burn injury in a liver transplant patient

Iraklis Delikonstantinou, B. Philp, D. Kamel, D. Barnes, Peter Dziewulski

Research output: Contribution to journalArticle

Abstract

Immunosuppressive therapy may aggravate the clinical course of a burned patient, primarily affecting wound healing and thus complicating permanent wound coverage. We hereby present the successful management of a 48-year-old female liver transplant recipient with a major burn injury, aiming to elucidate the effects of the patient’s immunosuppression on surgical treatment. After admission to the Burns ITU, the patient underwent serial debridement of the burn and coverage with cryopreserved allografts. Despite immunosuppression, no prolonged survival of the allo-epidermis was documented. Nevertheless, a variable degree of vascularized allo-dermis was clinically identified. She subsequently underwent skin autografting and was discharged home with most of the wounds healed. Although there are isolated reports of survival of skin allografts in immunocompromised patients, in our case the allografted skin did not provide permanent wound coverage. However, it permitted a staged surgical management, allowing the immunosuppressive regime to change, the skin donor sites to heal and it also provided a dermal scaffold for successful skin autografting.

Original languageFrench
Pages (from-to)206-208
Number of pages3
JournalAnnals of Burns and Fire Disasters
Volume29
Issue number3
StatePublished - Sep 1 2016
Externally publishedYes

Fingerprint

Transplants
Skin
Liver
Wounds and Injuries
Autologous Transplantation
Immunosuppressive Agents
Immunosuppression
Allografts
Immunocompromised Host
Debridement
Dermis
Burns
Epidermis
Wound Healing
Tissue Donors
Survival
Therapeutics

Keywords

  • Allografts
  • Burn injury
  • Immunosuppressive therapy
  • Liver transplant

ASJC Scopus subject areas

  • Emergency Medicine
  • Emergency
  • Critical Care and Intensive Care Medicine

Cite this

Delikonstantinou, I., Philp, B., Kamel, D., Barnes, D., & Dziewulski, P. (2016). Brûlure grave chez une transplantée hépatique. Annals of Burns and Fire Disasters, 29(3), 206-208.

Brûlure grave chez une transplantée hépatique. / Delikonstantinou, Iraklis; Philp, B.; Kamel, D.; Barnes, D.; Dziewulski, Peter.

In: Annals of Burns and Fire Disasters, Vol. 29, No. 3, 01.09.2016, p. 206-208.

Research output: Contribution to journalArticle

Delikonstantinou, I, Philp, B, Kamel, D, Barnes, D & Dziewulski, P 2016, 'Brûlure grave chez une transplantée hépatique', Annals of Burns and Fire Disasters, vol. 29, no. 3, pp. 206-208.
Delikonstantinou I, Philp B, Kamel D, Barnes D, Dziewulski P. Brûlure grave chez une transplantée hépatique. Annals of Burns and Fire Disasters. 2016 Sep 1;29(3):206-208.
Delikonstantinou, Iraklis ; Philp, B. ; Kamel, D. ; Barnes, D. ; Dziewulski, Peter. / Brûlure grave chez une transplantée hépatique. In: Annals of Burns and Fire Disasters. 2016 ; Vol. 29, No. 3. pp. 206-208.
@article{aae449f6e0e44da48b520f5d271e6298,
title = "Br{\^u}lure grave chez une transplant{\'e}e h{\'e}patique",
abstract = "Immunosuppressive therapy may aggravate the clinical course of a burned patient, primarily affecting wound healing and thus complicating permanent wound coverage. We hereby present the successful management of a 48-year-old female liver transplant recipient with a major burn injury, aiming to elucidate the effects of the patient’s immunosuppression on surgical treatment. After admission to the Burns ITU, the patient underwent serial debridement of the burn and coverage with cryopreserved allografts. Despite immunosuppression, no prolonged survival of the allo-epidermis was documented. Nevertheless, a variable degree of vascularized allo-dermis was clinically identified. She subsequently underwent skin autografting and was discharged home with most of the wounds healed. Although there are isolated reports of survival of skin allografts in immunocompromised patients, in our case the allografted skin did not provide permanent wound coverage. However, it permitted a staged surgical management, allowing the immunosuppressive regime to change, the skin donor sites to heal and it also provided a dermal scaffold for successful skin autografting.",
keywords = "Allografts, Burn injury, Immunosuppressive therapy, Liver transplant",
author = "Iraklis Delikonstantinou and B. Philp and D. Kamel and D. Barnes and Peter Dziewulski",
year = "2016",
month = "9",
day = "1",
language = "French",
volume = "29",
pages = "206--208",
journal = "Annals of Burns and Fire Disasters",
issn = "1121-1539",
publisher = "Mediterranean Council for Burns and Fire Disasters",
number = "3",

}

TY - JOUR

T1 - Brûlure grave chez une transplantée hépatique

AU - Delikonstantinou, Iraklis

AU - Philp, B.

AU - Kamel, D.

AU - Barnes, D.

AU - Dziewulski, Peter

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Immunosuppressive therapy may aggravate the clinical course of a burned patient, primarily affecting wound healing and thus complicating permanent wound coverage. We hereby present the successful management of a 48-year-old female liver transplant recipient with a major burn injury, aiming to elucidate the effects of the patient’s immunosuppression on surgical treatment. After admission to the Burns ITU, the patient underwent serial debridement of the burn and coverage with cryopreserved allografts. Despite immunosuppression, no prolonged survival of the allo-epidermis was documented. Nevertheless, a variable degree of vascularized allo-dermis was clinically identified. She subsequently underwent skin autografting and was discharged home with most of the wounds healed. Although there are isolated reports of survival of skin allografts in immunocompromised patients, in our case the allografted skin did not provide permanent wound coverage. However, it permitted a staged surgical management, allowing the immunosuppressive regime to change, the skin donor sites to heal and it also provided a dermal scaffold for successful skin autografting.

AB - Immunosuppressive therapy may aggravate the clinical course of a burned patient, primarily affecting wound healing and thus complicating permanent wound coverage. We hereby present the successful management of a 48-year-old female liver transplant recipient with a major burn injury, aiming to elucidate the effects of the patient’s immunosuppression on surgical treatment. After admission to the Burns ITU, the patient underwent serial debridement of the burn and coverage with cryopreserved allografts. Despite immunosuppression, no prolonged survival of the allo-epidermis was documented. Nevertheless, a variable degree of vascularized allo-dermis was clinically identified. She subsequently underwent skin autografting and was discharged home with most of the wounds healed. Although there are isolated reports of survival of skin allografts in immunocompromised patients, in our case the allografted skin did not provide permanent wound coverage. However, it permitted a staged surgical management, allowing the immunosuppressive regime to change, the skin donor sites to heal and it also provided a dermal scaffold for successful skin autografting.

KW - Allografts

KW - Burn injury

KW - Immunosuppressive therapy

KW - Liver transplant

UR - http://www.scopus.com/inward/record.url?scp=84992497215&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84992497215&partnerID=8YFLogxK

M3 - Article

VL - 29

SP - 206

EP - 208

JO - Annals of Burns and Fire Disasters

JF - Annals of Burns and Fire Disasters

SN - 1121-1539

IS - 3

ER -