A meta-analysis of mortality and major adverse cardiovascular and cerebrovascular events in patients undergoing transfemoral versus transapical transcatheter aortic valve implantation using edwards valve for severe aortic stenosis

Hemang B. Panchal, Vatsal Ladia, Parthiv Amin, Parthavkumar Patel, Sreenivas P. Veeranki, Kais Albalbissi, Timir Paul

Research output: Contribution to journalArticle

46 Scopus citations


The purpose of this meta-analysis was to compare 1 year mortality and major adverse cardiovascular and cerebrovascular events between transfemoral (TF) transcatheter aortic valve implantation (TAVI) and transapical (TA) TAVI performed using Edwards valves. PubMed, Embase, and the Cochrane Center Register of Controlled Trials were searched for studies published from January 2000 through March 2014. Seventeen studies met the inclusion criteria and were included in the analysis. This meta-analysis included total of 2,978 patients with severe aortic stenosis not eligible for traditional surgical procedures who underwent TF TAVI (n = 1,465) or TA TAVI (n = 1,513). End points were in-hospital, 30-day, and 1-year all-cause mortality, stroke, myocardial infarction, major bleeding, and major vascular complications. Odds ratios (ORs) with 95% confidence interval (CIs) were computed, and p values

Original languageEnglish (US)
Pages (from-to)1882-1890
Number of pages9
JournalAmerican Journal of Cardiology
Issue number12
StatePublished - 2014


ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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