A minor groove binding track in reverse transcriptase

K. Bebenek, W. A. Beard, T. A. Darden, L. Li, R. Prasad, B. A. Luxon, D. G. Gorenstein, S. H. Wilson, T. A. Kunkel

Research output: Contribution to journalArticle

110 Scopus citations


Evidence is presented indicating that processive synthesis by HIV-1 reverse transcriptase involves interactions between the minor groove of the template-primer and a discrete protein structural element, the minor groove binding track (MGBT).

Original languageEnglish (US)
Pages (from-to)194-197
Number of pages4
JournalNature Structural Biology
Issue number3
StatePublished - Mar 20 1997

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Genetics

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    Bebenek, K., Beard, W. A., Darden, T. A., Li, L., Prasad, R., Luxon, B. A., Gorenstein, D. G., Wilson, S. H., & Kunkel, T. A. (1997). A minor groove binding track in reverse transcriptase. Nature Structural Biology, 4(3), 194-197. https://doi.org/10.1038/nsb0397-194