A minor groove binding track in reverse transcriptase

K. Bebenek, W. A. Beard, T. A. Darden, L. Li, R. Prasad, B. A. Luxon, D. G. Gorenstein, S. H. Wilson, T. A. Kunkel

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

Evidence is presented indicating that processive synthesis by HIV-1 reverse transcriptase involves interactions between the minor groove of the template-primer and a discrete protein structural element, the minor groove binding track (MGBT).

Original languageEnglish (US)
Pages (from-to)194-197
Number of pages4
JournalNature Structural Biology
Volume4
Issue number3
DOIs
StatePublished - 1997
Externally publishedYes

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RNA-Directed DNA Polymerase
Proteins
Human immunodeficiency virus 1 reverse transcriptase
Protein Structural Elements

ASJC Scopus subject areas

  • Biochemistry
  • Structural Biology
  • Genetics

Cite this

Bebenek, K., Beard, W. A., Darden, T. A., Li, L., Prasad, R., Luxon, B. A., ... Kunkel, T. A. (1997). A minor groove binding track in reverse transcriptase. Nature Structural Biology, 4(3), 194-197. https://doi.org/10.1038/nsb0397-194

A minor groove binding track in reverse transcriptase. / Bebenek, K.; Beard, W. A.; Darden, T. A.; Li, L.; Prasad, R.; Luxon, B. A.; Gorenstein, D. G.; Wilson, S. H.; Kunkel, T. A.

In: Nature Structural Biology, Vol. 4, No. 3, 1997, p. 194-197.

Research output: Contribution to journalArticle

Bebenek, K, Beard, WA, Darden, TA, Li, L, Prasad, R, Luxon, BA, Gorenstein, DG, Wilson, SH & Kunkel, TA 1997, 'A minor groove binding track in reverse transcriptase', Nature Structural Biology, vol. 4, no. 3, pp. 194-197. https://doi.org/10.1038/nsb0397-194
Bebenek K, Beard WA, Darden TA, Li L, Prasad R, Luxon BA et al. A minor groove binding track in reverse transcriptase. Nature Structural Biology. 1997;4(3):194-197. https://doi.org/10.1038/nsb0397-194
Bebenek, K. ; Beard, W. A. ; Darden, T. A. ; Li, L. ; Prasad, R. ; Luxon, B. A. ; Gorenstein, D. G. ; Wilson, S. H. ; Kunkel, T. A. / A minor groove binding track in reverse transcriptase. In: Nature Structural Biology. 1997 ; Vol. 4, No. 3. pp. 194-197.
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