A model for reduced HIV-1 viral load monitoring in resource-limited settings

LeeAnn Bryant, Nathaniel Smith, Philip Keiser

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Viral load monitoring of antiretroviral therapy in low-income countries is rarely used because of high costs. Reducing the frequency of monitoring may make it financially feasible. Methods: We modeled three testing schemes: reduced viral load monitoring (RVLM) with CD4 count at baseline and viral load testing at 6, 36, and 60 months; United States Department of Health and Human Services (US DHHS) Treatment Guidelines; and World Health Organization (WHO) Guidelines using a cohort of 313 HIV-infected patients using Kaplan-Meier analysis. Results: Median time to detection of anti-retroviral therapy (ART) failure using RVLM was 147 days; using US DHHS, it was 115 days; and using WHO guidelines, it was 1110 days. Median time for the development of first thymidine analog mutation was 594 days. The cost of RVLM was significantly lower than US DHHS. Conclusions: RVLM detected failure significantly sooner than CD4 count monitoring alone at a lower cost than US DHHS monitoring. RVLM is a potentially effective method of monitoring ART in resource-limited settings.

Original languageEnglish (US)
Pages (from-to)67-71
Number of pages5
JournalJournal of the International Association of Providers of AIDS Care
Volume12
Issue number1
DOIs
StatePublished - Feb 2013

Fingerprint

Viral Load
HIV-1
United States Dept. of Health and Human Services
Guidelines
CD4 Lymphocyte Count
Costs and Cost Analysis
Kaplan-Meier Estimate
Therapeutics
Thymidine
HIV
Mutation

Keywords

  • AIDS
  • Monitoring
  • Treatment
  • Treatment failure
  • Viral load

ASJC Scopus subject areas

  • Immunology
  • Dermatology
  • Infectious Diseases

Cite this

A model for reduced HIV-1 viral load monitoring in resource-limited settings. / Bryant, LeeAnn; Smith, Nathaniel; Keiser, Philip.

In: Journal of the International Association of Providers of AIDS Care, Vol. 12, No. 1, 02.2013, p. 67-71.

Research output: Contribution to journalArticle

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