A model of ovine endotoxemia characterized by an increased cardiac output

P. Talke, A. Dunn, L. Lawlis, L. Sziebert, A. White, David Herndon, J. T. Flynn, D. Traber

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

High cardiac output sepsis is a major clinical problem. We have designed a sheep endotoxin model to simulate this condition and have evaluated how closely it approximates the clinical situation. The animals were prepared for chronic study by the implantation of cardiopulmonary catheters. One week later, endotoxin (0.75 μg/kg/30 min) was administered following baseline measurements, and the animals were studied for an additional 15 hr. From 6-15 hr after the administration of endotoxin, there was a statistically significant twofold increase in cardiac output. Simultaneously, the total peripheral vascular resistance and mean arterial pressure was reduced. Eicosanoid measurements made at this time indicated that the vasodilator prostanoid, prostacyclin, was not elevated. A high cardiac output (hyperdynamic) model of sepsis has thus been established by the 30 min infusion of a small quantitiy of endotoxin. Prostacyclin is not a mediator of this response.

Original languageEnglish
Pages (from-to)103-108
Number of pages6
JournalCirculatory Shock
Volume17
Issue number2
StatePublished - 1985
Externally publishedYes

Fingerprint

Endotoxemia
Endotoxins
Cardiac Output
Sheep
High Cardiac Output
Epoprostenol
Vascular Resistance
Sepsis
Eicosanoids
Vasodilator Agents
Prostaglandins
Arterial Pressure
Catheters

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Talke, P., Dunn, A., Lawlis, L., Sziebert, L., White, A., Herndon, D., ... Traber, D. (1985). A model of ovine endotoxemia characterized by an increased cardiac output. Circulatory Shock, 17(2), 103-108.

A model of ovine endotoxemia characterized by an increased cardiac output. / Talke, P.; Dunn, A.; Lawlis, L.; Sziebert, L.; White, A.; Herndon, David; Flynn, J. T.; Traber, D.

In: Circulatory Shock, Vol. 17, No. 2, 1985, p. 103-108.

Research output: Contribution to journalArticle

Talke, P, Dunn, A, Lawlis, L, Sziebert, L, White, A, Herndon, D, Flynn, JT & Traber, D 1985, 'A model of ovine endotoxemia characterized by an increased cardiac output', Circulatory Shock, vol. 17, no. 2, pp. 103-108.
Talke P, Dunn A, Lawlis L, Sziebert L, White A, Herndon D et al. A model of ovine endotoxemia characterized by an increased cardiac output. Circulatory Shock. 1985;17(2):103-108.
Talke, P. ; Dunn, A. ; Lawlis, L. ; Sziebert, L. ; White, A. ; Herndon, David ; Flynn, J. T. ; Traber, D. / A model of ovine endotoxemia characterized by an increased cardiac output. In: Circulatory Shock. 1985 ; Vol. 17, No. 2. pp. 103-108.
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