A moderate acute increase in physical activity enhances nutritive flow and the muscle protein anabolic response to mixed nutrient intake in older adults

Kyle L. Timmerman, Shaheen Dhanani, Erin L. Glynn, Christopher Fry, Micah J. Drummond, Kristofer Jennings, Blake Rasmussen, Elena Volpi

Research output: Contribution to journalArticle

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Abstract

Background: Nutrient stimulation of muscle protein anabolism is blunted with aging and may contribute to the development and progression of sarcopenia in older adults. This is likely due to insulin resistance of protein metabolism and/or endothelial dysfunction with a reduction in nutritive flow, both of which can be improved by aerobic exercise. Objective: Our objective was to determine whether increasing physical activity can enhance the muscle protein anabolic effect of essential amino acid (EAA) + sucrose intake in older subjects by improving nutritive flow and/or insulin signaling. Design: Using a randomized crossover design, we measured in older subjects [n = 6, 70 ± 3 y of age, BMI (in kg/m2) of 25 ± 1] the acute effects of increasing physical activity with aerobic exercise, as compared with normal sedentary lifestyle, on the response of blood flow, microvascular perfusion, insulin signaling, and muscle protein kinetics to EAA+sucrose intake. Results: No differences between treatment groups were found in the basal state. The change from the basal state in blood flow, muscle perfusion, phenylalanine delivery, net balance, and muscle protein synthesis during the consumption of EAA+sucrose was significantly higher after the exercise than after the control treatment (P < 0.05). Insulin signaling increased during EAA+sucrose ingestion in both groups (P < 0.05). Conclusions: Our data indicate that a prior bout of aerobic exercise increases the anabolic effect of nutrient intake in older adults. This effect appears to be mediated by an exercise-induced improvement in nutrient-stimulated vasodilation and nutrient delivery to muscle rather than to improved insulin signaling. This trial was registered at clinicaltrials.gov as NCT00690534.

Original languageEnglish (US)
Pages (from-to)1403-1412
Number of pages10
JournalAmerican Journal of Clinical Nutrition
Volume95
Issue number6
DOIs
StatePublished - Jun 1 2012

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Essential Amino Acids
Muscle Proteins
Sucrose
Insulin
Anabolic Agents
Food
Exercise
Perfusion
Sarcopenia
Sedentary Lifestyle
Muscles
Phenylalanine
Vasodilation
Cross-Over Studies
Insulin Resistance
Eating
Proteins

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

A moderate acute increase in physical activity enhances nutritive flow and the muscle protein anabolic response to mixed nutrient intake in older adults. / Timmerman, Kyle L.; Dhanani, Shaheen; Glynn, Erin L.; Fry, Christopher; Drummond, Micah J.; Jennings, Kristofer; Rasmussen, Blake; Volpi, Elena.

In: American Journal of Clinical Nutrition, Vol. 95, No. 6, 01.06.2012, p. 1403-1412.

Research output: Contribution to journalArticle

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AU - Drummond, Micah J.

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AU - Rasmussen, Blake

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