A modified vaccinia Ankara vector-based vaccine protects macaques from SARS-CoV-2 infection, immune pathology, and dysfunction in the lungs

Nanda Kishore Routhu; Narayanaiah Cheedarla; Sailaja Gangadhara; Venkata Satish Bollimpelli; Arun K. Boddapati; Ayalnesh Shiferaw; Sheikh Abdul Rahman; Anusmita Sahoo; Venkata Viswanadh Edara; Lilin Lai; Katharine Floyd; Shelly Wang; Stephanie Fischinger; Caroline Atyeo; Sally A. Shin; Sanjeev Gumber; Shannon Kirejczyk; Joyce Cohen; Sherrie M. Jean; Jennifer S. Wood; Fawn Connor-Stroud; Rachelle L. Stammen; Amit A. Upadhyay; Kathryn Pellegrini; David Montefiori; Pei Yong Shi; Vineet D. Menachery; Galit Alter; Thomas H. Vanderford; Steven E. Bosinger; Mehul S. Suthar; Rama Rao Amara

doi:10.1016/j.immuni.2021.02.001

A modified vaccinia Ankara vector-based vaccine protects macaques from SARS-CoV-2 infection, immune pathology, and dysfunction in the lungs

Nanda Kishore Routhu, Narayanaiah Cheedarla, Sailaja Gangadhara, Venkata Satish Bollimpelli, Arun K. Boddapati, Ayalnesh Shiferaw, Sheikh Abdul Rahman, Anusmita Sahoo, Venkata Viswanadh Edara, Lilin Lai, Katharine Floyd, Shelly Wang, Stephanie Fischinger, Caroline Atyeo, Sally A. Shin, Sanjeev Gumber, Shannon Kirejczyk, Joyce Cohen, Sherrie M. Jean, Jennifer S. WoodFawn Connor-Stroud, Rachelle L. Stammen, Amit A. Upadhyay, Kathryn Pellegrini, David Montefiori, Pei Yong Shi, Vineet D. Menachery, Galit Alter, Thomas H. Vanderford, Steven E. Bosinger, Mehul S. Suthar, Rama Rao Amara

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

Modified vaccinia Ankara (MVA) vector-based vaccines are attractive because of their excellent safety and ability to induce long-lived humoral and cellular immunity in humans. Routhu et al. show that an MVA-based COVID-19 vaccine encoding prefusion-stabilized spike (MVA/S) induces strong neutralizing antibody and CD8⁺ T cell responses and protects macaques from SARS-CoV2 infection, immunopathology, and infection-induced B cell abnormalities in the lungs.

Original language	English (US)
Pages (from-to)	542-556.e9
Journal	Immunity
Volume	54
Issue number	3
DOIs	https://doi.org/10.1016/j.immuni.2021.02.001
State	Published - Mar 9 2021

Keywords

CD8 T cells
COVID-19
Modified Vaccinia Ankara
Neutralizing antibody
Protection
Rhesus macaques
SARS-CoV-2
Spike
Vaccine

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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10.1016/j.immuni.2021.02.001

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Routhu, N. K., Cheedarla, N., Gangadhara, S., Bollimpelli, V. S., Boddapati, A. K., Shiferaw, A., Rahman, S. A., Sahoo, A., Edara, V. V., Lai, L., Floyd, K., Wang, S., Fischinger, S., Atyeo, C., Shin, S. A., Gumber, S., Kirejczyk, S., Cohen, J., Jean, S. M., ... Amara, R. R. (2021). A modified vaccinia Ankara vector-based vaccine protects macaques from SARS-CoV-2 infection, immune pathology, and dysfunction in the lungs. Immunity, 54(3), 542-556.e9. https://doi.org/10.1016/j.immuni.2021.02.001

Routhu, NK, Cheedarla, N, Gangadhara, S, Bollimpelli, VS, Boddapati, AK, Shiferaw, A, Rahman, SA, Sahoo, A, Edara, VV, Lai, L, Floyd, K, Wang, S, Fischinger, S, Atyeo, C, Shin, SA, Gumber, S, Kirejczyk, S, Cohen, J, Jean, SM, Wood, JS, Connor-Stroud, F, Stammen, RL, Upadhyay, AA, Pellegrini, K, Montefiori, D, Shi, PY, Menachery, VD, Alter, G, Vanderford, TH, Bosinger, SE, Suthar, MS & Amara, RR 2021, 'A modified vaccinia Ankara vector-based vaccine protects macaques from SARS-CoV-2 infection, immune pathology, and dysfunction in the lungs', Immunity, vol. 54, no. 3, pp. 542-556.e9. https://doi.org/10.1016/j.immuni.2021.02.001

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title = "A modified vaccinia Ankara vector-based vaccine protects macaques from SARS-CoV-2 infection, immune pathology, and dysfunction in the lungs",

abstract = "Modified vaccinia Ankara (MVA) vector-based vaccines are attractive because of their excellent safety and ability to induce long-lived humoral and cellular immunity in humans. Routhu et al. show that an MVA-based COVID-19 vaccine encoding prefusion-stabilized spike (MVA/S) induces strong neutralizing antibody and CD8+ T cell responses and protects macaques from SARS-CoV2 infection, immunopathology, and infection-induced B cell abnormalities in the lungs.",

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AU - Cheedarla, Narayanaiah

AU - Gangadhara, Sailaja

AU - Bollimpelli, Venkata Satish

AU - Boddapati, Arun K.

AU - Shiferaw, Ayalnesh

AU - Rahman, Sheikh Abdul

AU - Sahoo, Anusmita

AU - Edara, Venkata Viswanadh

AU - Lai, Lilin

AU - Floyd, Katharine

AU - Wang, Shelly

AU - Fischinger, Stephanie

AU - Atyeo, Caroline

AU - Shin, Sally A.

AU - Gumber, Sanjeev

AU - Kirejczyk, Shannon

AU - Cohen, Joyce

AU - Jean, Sherrie M.

AU - Wood, Jennifer S.

AU - Connor-Stroud, Fawn

AU - Stammen, Rachelle L.

AU - Upadhyay, Amit A.

AU - Pellegrini, Kathryn

AU - Montefiori, David

AU - Shi, Pei Yong

AU - Menachery, Vineet D.

AU - Alter, Galit

AU - Vanderford, Thomas H.

AU - Bosinger, Steven E.

AU - Suthar, Mehul S.

AU - Amara, Rama Rao

PY - 2021/3/9

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A modified vaccinia Ankara vector-based vaccine protects macaques from SARS-CoV-2 infection, immune pathology, and dysfunction in the lungs

Abstract

Keywords

ASJC Scopus subject areas

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