TY - JOUR
T1 - A modified vaccinia Ankara vector-based vaccine protects macaques from SARS-CoV-2 infection, immune pathology, and dysfunction in the lungs
AU - Routhu, Nanda Kishore
AU - Cheedarla, Narayanaiah
AU - Gangadhara, Sailaja
AU - Bollimpelli, Venkata Satish
AU - Boddapati, Arun K.
AU - Shiferaw, Ayalnesh
AU - Rahman, Sheikh Abdul
AU - Sahoo, Anusmita
AU - Edara, Venkata Viswanadh
AU - Lai, Lilin
AU - Floyd, Katharine
AU - Wang, Shelly
AU - Fischinger, Stephanie
AU - Atyeo, Caroline
AU - Shin, Sally A.
AU - Gumber, Sanjeev
AU - Kirejczyk, Shannon
AU - Cohen, Joyce
AU - Jean, Sherrie M.
AU - Wood, Jennifer S.
AU - Connor-Stroud, Fawn
AU - Stammen, Rachelle L.
AU - Upadhyay, Amit A.
AU - Pellegrini, Kathryn
AU - Montefiori, David
AU - Shi, Pei Yong
AU - Menachery, Vineet D.
AU - Alter, Galit
AU - Vanderford, Thomas H.
AU - Bosinger, Steven E.
AU - Suthar, Mehul S.
AU - Amara, Rama Rao
N1 - Publisher Copyright:
© 2021 Elsevier Inc.
PY - 2021/3/9
Y1 - 2021/3/9
N2 - Modified vaccinia Ankara (MVA) vector-based vaccines are attractive because of their excellent safety and ability to induce long-lived humoral and cellular immunity in humans. Routhu et al. show that an MVA-based COVID-19 vaccine encoding prefusion-stabilized spike (MVA/S) induces strong neutralizing antibody and CD8+ T cell responses and protects macaques from SARS-CoV2 infection, immunopathology, and infection-induced B cell abnormalities in the lungs.
AB - Modified vaccinia Ankara (MVA) vector-based vaccines are attractive because of their excellent safety and ability to induce long-lived humoral and cellular immunity in humans. Routhu et al. show that an MVA-based COVID-19 vaccine encoding prefusion-stabilized spike (MVA/S) induces strong neutralizing antibody and CD8+ T cell responses and protects macaques from SARS-CoV2 infection, immunopathology, and infection-induced B cell abnormalities in the lungs.
KW - CD8 T cells
KW - COVID-19
KW - Modified Vaccinia Ankara
KW - Neutralizing antibody
KW - Protection
KW - Rhesus macaques
KW - SARS-CoV-2
KW - Spike
KW - Vaccine
UR - http://www.scopus.com/inward/record.url?scp=85101565118&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85101565118&partnerID=8YFLogxK
U2 - 10.1016/j.immuni.2021.02.001
DO - 10.1016/j.immuni.2021.02.001
M3 - Article
C2 - 33631118
AN - SCOPUS:85101565118
SN - 1074-7613
VL - 54
SP - 542-556.e9
JO - Immunity
JF - Immunity
IS - 3
ER -