A multicenter clinical trial of a biosynthetic skin replacement, dermagraft-TC, compared with cryopreserved human cadaver skin for temporary coverage of excised burn wounds

Gary F. Purdue, John L. Hunt, Joseph M. Still, Edward J. Law, David Herndon, I. William Goldfarb, William R. Schiller, John F. Hansbrough, William L. Hickerson, Harvey N. Himel, G. Patrick Kealey, John Twomey, Anne E. Missavage, Lynn D. Solem, Michelle Davis, Mark Totoritis, Gary D. Gentzkow

Research output: Contribution to journalArticle

113 Scopus citations

Abstract

This multicenter study compared the use of a biosynthetic human skin substitute with frozen human cadaver allograft for the temporary closure of excised burn wounds. Dermagraft-TC (Advanced Tissue Sciences, Inc.) (DG-TC) consists of a synthetic material onto which human neonatal fibroblasts are cultured. Burn wounds in 66 patients with a mean age of 36 years and a mean burn size of 44% total body surface area (28% total body surface area full- thickness) were surgically excised. Two comparable sites, each approximately 1% total body surface area in size, were randomized to receive either DG-TC or allograft. Both sites were then treated in the same manner. When clinically indicated (>5 days after application) both skin replacements were removed, and the wound beds were evaluated and prepared for grafting. DG-TC was equivalent or superior to allograft with regard to autograft take at postautograft day 14. DG-TC was also easier to remove, had no epidermal slough, and resulted in less bleeding than did allograft while maintaining an adequate wound bed. Overall satisfaction was better with DG-TC.

Original languageEnglish (US)
Pages (from-to)52-57
Number of pages6
JournalJournal of Burn Care and Rehabilitation
Volume18
Issue number1 I
DOIs
StatePublished - Jan 1997
Externally publishedYes

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ASJC Scopus subject areas

  • Rehabilitation
  • Surgery
  • Nursing(all)
  • Health Professions(all)
  • Emergency Medicine

Cite this

Purdue, G. F., Hunt, J. L., Still, J. M., Law, E. J., Herndon, D., Goldfarb, I. W., Schiller, W. R., Hansbrough, J. F., Hickerson, W. L., Himel, H. N., Kealey, G. P., Twomey, J., Missavage, A. E., Solem, L. D., Davis, M., Totoritis, M., & Gentzkow, G. D. (1997). A multicenter clinical trial of a biosynthetic skin replacement, dermagraft-TC, compared with cryopreserved human cadaver skin for temporary coverage of excised burn wounds. Journal of Burn Care and Rehabilitation, 18(1 I), 52-57. https://doi.org/10.1097/00004630-199701000-00009