@article{ac8b986021c34a608310fe99ebfc5a8b,
title = "A Multicomponent Animal Virus Isolated from Mosquitoes",
abstract = "RNA viruses exhibit a variety of genome organization strategies, including multicomponent genomes in which each segment is packaged separately. Although multicomponent genomes are common among viruses infecting plants and fungi, their prevalence among those infecting animals remains unclear. We characterize a multicomponent RNA virus isolated from mosquitoes, designated Guaico Culex virus (GCXV). GCXV belongs to a diverse clade of segmented viruses (Jingmenvirus) related to the prototypically unsegmented Flaviviridae. The GCXV genome comprises five segments, each of which appears to be separately packaged. The smallest segment is not required for replication, and its presence is variable in natural infections. We also describe a variant of Jingmen tick virus, another Jingmenvirus, sequenced from a Ugandan red colobus monkey, thus expanding the host range of this segmented and likely multicomponent virus group. Collectively, this study provides evidence for the existence of multicomponent animal viruses and their potential relevance for animal and human health.",
author = "Ladner, {Jason T.} and Wiley, {Michael R.} and Brett Beitzel and Auguste, {Albert J.} and Dupuis, {Alan P.} and Lindquist, {Michael E.} and Sibley, {Samuel D.} and Kota, {Krishna P.} and David Fetterer and Gillian Eastwood and David Kimmel and Karla Prieto and Hilda Guzman and Aliota, {Matthew T.} and Daniel Reyes and Brueggemann, {Ernst E.} and {St. John}, Lena and David Hyeroba and Michael Lauck and Friedrich, {Thomas C.} and O'Connor, {David H.} and Gestole, {Marie C.} and Cazares, {Lisa H.} and Popov, {Vsevolod L.} and Fanny Castro-Llanos and Kochel, {Tadeusz J.} and Tara Kenny and Bailey White and Ward, {Michael D.} and Loaiza, {Jose R.} and Goldberg, {Tony L.} and Weaver, {Scott C.} and Kramer, {Laura D.} and Tesh, {Robert B.} and Gustavo Palacios",
note = "Funding Information: Work at U.S. Army Medical Research Institute of Infectious Diseases was funded by the Defense Threat Reduction Agency, project 1881290. Work at UTMB was supported by NIH contract HHSN272201000040I/HHSN27200004/D04 to R.B.T. A.J.A. was supported by the James W. McLaughlin Endowment fund. Mosquito collection in Panama was funded by Smithsonian Tropical Research Institute – Environmental Protection Agency grant DW33-92296801-0 to Montira J. Pongsiri. Work in Panama was supported by a Robert E. Shope fellowship awarded to G.E. Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",
year = "2016",
month = sep,
day = "14",
doi = "10.1016/j.chom.2016.07.011",
language = "English (US)",
volume = "20",
pages = "357--367",
journal = "Cell Host and Microbe",
issn = "1931-3128",
publisher = "Cell Press",
number = "3",
}