A new allele within the transmembrane region of the human MICA gene with seven GCT repeats

B. Rueda, M. Pascual, M. A. López-Nevot, Emilio Gonzalez, Javier Martín

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30 Scopus citations


Major histocompatibility complex class I chain-related genes (MIC) belong to a multicopy gene family located within the HLA class I region of chromosome 6. They encode for proteins that have a completely different organization, expression, and products from classical HLA class I gene products. One member of this family is the MICA gene, which is characterized by its high degree of polymorphism, with over 50 MICA alleles described. Moreover, MICA exon 5 presents a microsatellite polymorphism consisting of a variable number of GCT repeats that encode for 4, 5, 6, 9, or 10 alanine residues, and a variant (MICA A5.1) that includes a nucleotide insertion (GCT→GGCT). In this study, we report a novel allele in the transmembrane region of the MICA gene consisting of seven GCT repeats found in a family based study of MICA polymorphism in celiac disease.



  • HLA
  • MICA gene
  • Microsatellite
  • Polymorphism

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

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