A New Component in Synaptic Plasticity

Upregulation of Kinesin in the Neurons of the Gill-Withdrawal Reflex

Sathyanarayanan V. Puthanveettil, Francisco J. Monje, Maria Concetta Miniaci, Yun Beom Choi, Kevin A. Karl, Eugene Khandros, Mary Ann Gawinowicz, Michael Sheetz, Eric R. Kandel

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

To explore how gene products, required for the initiation of synaptic growth, move from the cell body of the sensory neuron to its presynaptic terminals, and from the cell body of the motor neuron to its postsynaptic dendritic spines, we have investigated the anterograde transport machinery in both the sensory and motor neurons of the gill-withdrawal reflex of Aplysia. We found that the induction of long-term facilitation (LTF) by repeated applications of serotonin, a modulatory transmitter released during learning in Aplysia, requires upregulation of kinesin heavy chain (KHC) in both pre- and postsynaptic neurons. Indeed, upregulation of KHC in the presynaptic neurons alone is sufficient for the induction of LTF. However, KHC is not required for the persistence of LTF. Thus, in addition to transcriptional activation in the nucleus and local protein synthesis at the synapse, our studies have identified a third component critical for long-term learning-related plasticity: the coordinated upregulation of kinesin-mediated transport.

Original languageEnglish (US)
Pages (from-to)960-973
Number of pages14
JournalCell
Volume135
Issue number5
DOIs
StatePublished - Nov 28 2008
Externally publishedYes

Fingerprint

Kinesin
Neuronal Plasticity
Neurons
Plasticity
Reflex
Up-Regulation
Aplysia
Motor Neurons
Sensory Receptor Cells
Learning
Dendritic Spines
Cells
Presynaptic Terminals
Synapses
Transcriptional Activation
Serotonin
Machinery
Transmitters
Genes
Chemical activation

Keywords

  • CELLBIO
  • MOLNEURO
  • PROTEINS

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Puthanveettil, S. V., Monje, F. J., Miniaci, M. C., Choi, Y. B., Karl, K. A., Khandros, E., ... Kandel, E. R. (2008). A New Component in Synaptic Plasticity: Upregulation of Kinesin in the Neurons of the Gill-Withdrawal Reflex. Cell, 135(5), 960-973. https://doi.org/10.1016/j.cell.2008.11.003

A New Component in Synaptic Plasticity : Upregulation of Kinesin in the Neurons of the Gill-Withdrawal Reflex. / Puthanveettil, Sathyanarayanan V.; Monje, Francisco J.; Miniaci, Maria Concetta; Choi, Yun Beom; Karl, Kevin A.; Khandros, Eugene; Gawinowicz, Mary Ann; Sheetz, Michael; Kandel, Eric R.

In: Cell, Vol. 135, No. 5, 28.11.2008, p. 960-973.

Research output: Contribution to journalArticle

Puthanveettil, SV, Monje, FJ, Miniaci, MC, Choi, YB, Karl, KA, Khandros, E, Gawinowicz, MA, Sheetz, M & Kandel, ER 2008, 'A New Component in Synaptic Plasticity: Upregulation of Kinesin in the Neurons of the Gill-Withdrawal Reflex', Cell, vol. 135, no. 5, pp. 960-973. https://doi.org/10.1016/j.cell.2008.11.003
Puthanveettil SV, Monje FJ, Miniaci MC, Choi YB, Karl KA, Khandros E et al. A New Component in Synaptic Plasticity: Upregulation of Kinesin in the Neurons of the Gill-Withdrawal Reflex. Cell. 2008 Nov 28;135(5):960-973. https://doi.org/10.1016/j.cell.2008.11.003
Puthanveettil, Sathyanarayanan V. ; Monje, Francisco J. ; Miniaci, Maria Concetta ; Choi, Yun Beom ; Karl, Kevin A. ; Khandros, Eugene ; Gawinowicz, Mary Ann ; Sheetz, Michael ; Kandel, Eric R. / A New Component in Synaptic Plasticity : Upregulation of Kinesin in the Neurons of the Gill-Withdrawal Reflex. In: Cell. 2008 ; Vol. 135, No. 5. pp. 960-973.
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