A new in vivo assay of human lymphocyte-mediated immunity to melanoma

Raymond E. Richmond, Courtney Townsend, Donald L. Morton

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Lymphocytes from melanoma patients more frequently inhibited the growth of human melanoma cells in the hamster cheek pouch than did lymphocytes from normal donors. Growth inhibition was accomplished with a much lower ratio of target cells to lymphocytes than in in vitro assays. The hamster cheek pouch assay can be used to study the relationship of blocking factors and humoral antibodies to cell-mediated immunity against human cancers.

Original languageEnglish (US)
Pages (from-to)345-350
Number of pages6
JournalSurgery
Volume81
Issue number3
StatePublished - 1977
Externally publishedYes

Fingerprint

Immunity
Melanoma
Cheek
Lymphocytes
Cricetinae
Growth
Cellular Immunity
Tissue Donors
Antibodies
Neoplasms
In Vitro Techniques
blocking factor

ASJC Scopus subject areas

  • Surgery

Cite this

Richmond, R. E., Townsend, C., & Morton, D. L. (1977). A new in vivo assay of human lymphocyte-mediated immunity to melanoma. Surgery, 81(3), 345-350.

A new in vivo assay of human lymphocyte-mediated immunity to melanoma. / Richmond, Raymond E.; Townsend, Courtney; Morton, Donald L.

In: Surgery, Vol. 81, No. 3, 1977, p. 345-350.

Research output: Contribution to journalArticle

Richmond, RE, Townsend, C & Morton, DL 1977, 'A new in vivo assay of human lymphocyte-mediated immunity to melanoma', Surgery, vol. 81, no. 3, pp. 345-350.
Richmond, Raymond E. ; Townsend, Courtney ; Morton, Donald L. / A new in vivo assay of human lymphocyte-mediated immunity to melanoma. In: Surgery. 1977 ; Vol. 81, No. 3. pp. 345-350.
@article{9689dc1865a741efa0a072db6715dcc1,
title = "A new in vivo assay of human lymphocyte-mediated immunity to melanoma",
abstract = "Lymphocytes from melanoma patients more frequently inhibited the growth of human melanoma cells in the hamster cheek pouch than did lymphocytes from normal donors. Growth inhibition was accomplished with a much lower ratio of target cells to lymphocytes than in in vitro assays. The hamster cheek pouch assay can be used to study the relationship of blocking factors and humoral antibodies to cell-mediated immunity against human cancers.",
author = "Richmond, {Raymond E.} and Courtney Townsend and Morton, {Donald L.}",
year = "1977",
language = "English (US)",
volume = "81",
pages = "345--350",
journal = "Surgery",
issn = "0039-6060",
publisher = "Mosby Inc.",
number = "3",

}

TY - JOUR

T1 - A new in vivo assay of human lymphocyte-mediated immunity to melanoma

AU - Richmond, Raymond E.

AU - Townsend, Courtney

AU - Morton, Donald L.

PY - 1977

Y1 - 1977

N2 - Lymphocytes from melanoma patients more frequently inhibited the growth of human melanoma cells in the hamster cheek pouch than did lymphocytes from normal donors. Growth inhibition was accomplished with a much lower ratio of target cells to lymphocytes than in in vitro assays. The hamster cheek pouch assay can be used to study the relationship of blocking factors and humoral antibodies to cell-mediated immunity against human cancers.

AB - Lymphocytes from melanoma patients more frequently inhibited the growth of human melanoma cells in the hamster cheek pouch than did lymphocytes from normal donors. Growth inhibition was accomplished with a much lower ratio of target cells to lymphocytes than in in vitro assays. The hamster cheek pouch assay can be used to study the relationship of blocking factors and humoral antibodies to cell-mediated immunity against human cancers.

UR - http://www.scopus.com/inward/record.url?scp=0017325317&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017325317&partnerID=8YFLogxK

M3 - Article

C2 - 300180

AN - SCOPUS:0017325317

VL - 81

SP - 345

EP - 350

JO - Surgery

JF - Surgery

SN - 0039-6060

IS - 3

ER -