A new metal-free benzorhodol-based photoluminophore selective for carbon monoxide detection applicable in both in vitro and in vivo bioimaging

Ejaj Ahmmed, Debanjan Sarkar, Asit Mondal, Nimai Chandra Saha, Sankar Bhattacharyya, Pabitra Chattopadhyay

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

A new benzorhodol-based non-fluorescent organic frame (DEB-CO) detects carbon monoxide (CO) selectively through a spirolactam ring-opening mechanism. Herein, the selective off-on fluorogenic behavior of this probe towards CO has been achieved without any assistance of precious and hazardous metals (e.g. Pd2+) as additional substrates. Moreover, the red-emissive probe motivated us to apply in situ tracing in mice and living cells. The selective off-on fluorogenic behavior of this probe towards CO originating from CORM-3 in vitro and in vivo with a limit of detection as low as 64.29 nM (for CORM-3) has been observed. Additionally, this probe is capable of sensing toxic carbon monoxide gas. This probe has also been utilized to detect intracellular CO in MCF7 cells (in vitro) and to spot the distribution of CO in mice (in vivo) by acquiring bioimages with the help of confocal microscopy, which indicates that DEB-CO is a smart competent probe for this purpose.

Original languageEnglish (US)
Pages (from-to)3196-3202
Number of pages7
JournalAnalytical Methods
Volume14
Issue number33
DOIs
StatePublished - Jul 21 2022
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • General Chemical Engineering
  • General Engineering

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