Abstract
A new benzorhodol-based non-fluorescent organic frame (DEB-CO) detects carbon monoxide (CO) selectively through a spirolactam ring-opening mechanism. Herein, the selective off-on fluorogenic behavior of this probe towards CO has been achieved without any assistance of precious and hazardous metals (e.g. Pd2+) as additional substrates. Moreover, the red-emissive probe motivated us to apply in situ tracing in mice and living cells. The selective off-on fluorogenic behavior of this probe towards CO originating from CORM-3 in vitro and in vivo with a limit of detection as low as 64.29 nM (for CORM-3) has been observed. Additionally, this probe is capable of sensing toxic carbon monoxide gas. This probe has also been utilized to detect intracellular CO in MCF7 cells (in vitro) and to spot the distribution of CO in mice (in vivo) by acquiring bioimages with the help of confocal microscopy, which indicates that DEB-CO is a smart competent probe for this purpose.
Original language | English (US) |
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Pages (from-to) | 3196-3202 |
Number of pages | 7 |
Journal | Analytical Methods |
Volume | 14 |
Issue number | 33 |
DOIs | |
State | Published - Jul 21 2022 |
Externally published | Yes |
ASJC Scopus subject areas
- Analytical Chemistry
- General Chemical Engineering
- General Engineering