A new role for cryptochrome in a Drosophila circadian oscillator

Balaji Krishnan, Joel D. Levine, M. Kathlea S Lynch, Harold B. Dowse, Pablo Funes, Jeffrey C. Hall, Paul E. Hardin, Stuart E. Dryer

Research output: Contribution to journalArticle

186 Citations (Scopus)

Abstract

Cryptochromes are flavin/pterin-containing proteins that are involved in circadian clock function in Drosophila and mice. In mice, the cryptochromes Cry1 and Cry2 are integral components of the circadian oscillator within the brain and contribute to circadian photoreception in the retina. In Drosophila, cryptochrome (CRY) acts as a photoreceptor that mediates light input to circadian oscillators in both brain and peripheral tissue. A Drosophila cry mutant, cryb, leaves circadian oscillator function intact in central circadian pacemaker neurons but renders peripheral circadian oscillators largely arrhythmic. Although this arrhythmicity could be caused by a loss of light entrainment, it is also consistent with a role for CRY in the oscillator. A peripheral oscillator drives circadian olfactory responses in Drosophila antennae. Here we show that CRY contributes to oscillator function and physiological output rhythms in the antenna during and after entrainment to light-dark cycles and after photic input is eliminated by entraining flies to temperature cycles. These results demonstrate a photoreceptor-independent role for CRY in the periphery and imply fundamental differences between central and peripheral oscillator mechanisms in Drosophila.

Original languageEnglish (US)
Pages (from-to)313-317
Number of pages5
JournalNature
Volume411
Issue number6835
DOIs
StatePublished - May 17 2001
Externally publishedYes

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Cryptochromes
Drosophila
Pterins
Light
Circadian Clocks
Photoperiod
Brain
Diptera
Retina
Neurons
Temperature

ASJC Scopus subject areas

  • General

Cite this

Krishnan, B., Levine, J. D., Lynch, M. K. S., Dowse, H. B., Funes, P., Hall, J. C., ... Dryer, S. E. (2001). A new role for cryptochrome in a Drosophila circadian oscillator. Nature, 411(6835), 313-317. https://doi.org/10.1038/35077094

A new role for cryptochrome in a Drosophila circadian oscillator. / Krishnan, Balaji; Levine, Joel D.; Lynch, M. Kathlea S; Dowse, Harold B.; Funes, Pablo; Hall, Jeffrey C.; Hardin, Paul E.; Dryer, Stuart E.

In: Nature, Vol. 411, No. 6835, 17.05.2001, p. 313-317.

Research output: Contribution to journalArticle

Krishnan, B, Levine, JD, Lynch, MKS, Dowse, HB, Funes, P, Hall, JC, Hardin, PE & Dryer, SE 2001, 'A new role for cryptochrome in a Drosophila circadian oscillator', Nature, vol. 411, no. 6835, pp. 313-317. https://doi.org/10.1038/35077094
Krishnan B, Levine JD, Lynch MKS, Dowse HB, Funes P, Hall JC et al. A new role for cryptochrome in a Drosophila circadian oscillator. Nature. 2001 May 17;411(6835):313-317. https://doi.org/10.1038/35077094
Krishnan, Balaji ; Levine, Joel D. ; Lynch, M. Kathlea S ; Dowse, Harold B. ; Funes, Pablo ; Hall, Jeffrey C. ; Hardin, Paul E. ; Dryer, Stuart E. / A new role for cryptochrome in a Drosophila circadian oscillator. In: Nature. 2001 ; Vol. 411, No. 6835. pp. 313-317.
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