A new role for phospholipase A2: protection of membranes from lipid peroxidation damage

Frederik J.G.M. van Kuijk; Alex Sevanian; Garry J. Handelman; Edward A. Dratz

doi:10.1016/0968-0004(87)90014-4

A new role for phospholipase A₂: protection of membranes from lipid peroxidation damage

Frederik J.G.M. van Kuijk
, Alex Sevanian
, Garry J. Handelman
, Edward A. Dratz

Research output: Contribution to journal › Article › peer-review

388 Scopus citations

Abstract

Recently it was discovered that phospholipase A₂ preferentially hydrolyses peroxidized fatty acid esters in phospholipid membranes. Release of the peroxidized fatty acids from the membrane was found to be an absolute requirement for glutathione peroxidase to reduce and detoxify fatty acid hydroperoxides in membranes. On the basis of these findings we propose a new role for phospholipase A₂ in protecting membranes from oxidative injury.

Original language	English (US)
Pages (from-to)	31-34
Number of pages	4
Journal	Trends in biochemical sciences
Volume	12
Issue number	C
DOIs	https://doi.org/10.1016/0968-0004(87)90014-4
State	Published - 1987
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology

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10.1016/0968-0004(87)90014-4

Cite this

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title = "A new role for phospholipase A2: protection of membranes from lipid peroxidation damage",

abstract = "Recently it was discovered that phospholipase A2 preferentially hydrolyses peroxidized fatty acid esters in phospholipid membranes. Release of the peroxidized fatty acids from the membrane was found to be an absolute requirement for glutathione peroxidase to reduce and detoxify fatty acid hydroperoxides in membranes. On the basis of these findings we propose a new role for phospholipase A2 in protecting membranes from oxidative injury.",

author = "\{van Kuijk\}, \{Frederik J.G.M.\} and Alex Sevanian and Handelman, \{Garry J.\} and Dratz, \{Edward A.\}",

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AU - van Kuijk, Frederik J.G.M.

AU - Sevanian, Alex

AU - Handelman, Garry J.

AU - Dratz, Edward A.

PY - 1987

Y1 - 1987

N2 - Recently it was discovered that phospholipase A2 preferentially hydrolyses peroxidized fatty acid esters in phospholipid membranes. Release of the peroxidized fatty acids from the membrane was found to be an absolute requirement for glutathione peroxidase to reduce and detoxify fatty acid hydroperoxides in membranes. On the basis of these findings we propose a new role for phospholipase A2 in protecting membranes from oxidative injury.

AB - Recently it was discovered that phospholipase A2 preferentially hydrolyses peroxidized fatty acid esters in phospholipid membranes. Release of the peroxidized fatty acids from the membrane was found to be an absolute requirement for glutathione peroxidase to reduce and detoxify fatty acid hydroperoxides in membranes. On the basis of these findings we propose a new role for phospholipase A2 in protecting membranes from oxidative injury.

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DO - 10.1016/0968-0004(87)90014-4

M3 - Article

AN - SCOPUS:0023120755

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JO - Trends in biochemical sciences

JF - Trends in biochemical sciences

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ER -

A new role for phospholipase A₂: protection of membranes from lipid peroxidation damage

Abstract

ASJC Scopus subject areas

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