A new subtype of a natural viral inhibitor (CVI) that is stable in the gastrointestinal tract

Jody L. Baron, Jui Lien Li, M. Louese McKerlie, Joseph Shabot, Dorian H. Coppenhaver

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A virus inhibitor found in gastric secretions and in extracts from gastrointestinal tissues is described. The inhibitor shares a number of characteristics with the recently described contact-blocking virus inhibitor (CVI), which is produced by unstimulated cells in culture, and occurs naturally in some body fluids. The new inhibitor, which we have designated gastrointestinal-CVI (GI-CVI) is similar to the originally described CVI in its resistance to denaturation by acid and alkali, stability at 100 °C, and broad antiviral action. GI-CVI can be distinguished from the previously described material by its resistance to proteolytic inactivation and enhanced heat stability, however. This new virus inhibitor has been found in significant titers in gastrointestinal secretions and tissue extracts from three mammalian species.

Original languageEnglish (US)
Pages (from-to)241-247
Number of pages7
JournalMicrobial Pathogenesis
Volume1
Issue number3
DOIs
StatePublished - 1986

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Gastrointestinal Tract
Viruses
Tissue Extracts
Alkalies
Body Fluids
Antiviral Agents
Stomach
Cell Culture Techniques
Hot Temperature
Acids

Keywords

  • heat stability
  • Newcastle disease virus
  • vaccinia virus
  • virus inhibition

ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases

Cite this

A new subtype of a natural viral inhibitor (CVI) that is stable in the gastrointestinal tract. / Baron, Jody L.; Li, Jui Lien; McKerlie, M. Louese; Shabot, Joseph; Coppenhaver, Dorian H.

In: Microbial Pathogenesis, Vol. 1, No. 3, 1986, p. 241-247.

Research output: Contribution to journalArticle

Baron, Jody L. ; Li, Jui Lien ; McKerlie, M. Louese ; Shabot, Joseph ; Coppenhaver, Dorian H. / A new subtype of a natural viral inhibitor (CVI) that is stable in the gastrointestinal tract. In: Microbial Pathogenesis. 1986 ; Vol. 1, No. 3. pp. 241-247.
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