A new system for determining the causes of stillbirth

Donald J. Dudley, Robert Goldenberg, Deborah Conway, Robert M. Silver, George Saade, Michael W. Varner, Halit Pinar, Donald Coustan, Radek Bukowski, Barbara Stoll, Matthew A. Koch, Corette B. Parker, Uma M. Reddy

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Objective: To describe the methods for assigning the cause of death for stillbirths enrolled in the Stillbirth Collaborative Research Network (SCRN). Methods: A complete evaluation, including postmortem examination, placental pathology, medical record abstraction, and maternal interview was available on 512 stillbirths among 500 women. These 512 stillbirths were evaluated for cause of death using the definitions outlined in this report. Using the best available evidence, SCRN investigators developed a new methodology to assign the cause of death of stillbirths using clinical, postmortem, and placental pathology data. This new tool, designated the Initial Causes of Fetal Death, incorporates known causes of death and assigns them as possible or probable based on strict diagnostic criteria, derived from published references and pathophysiologic sequences that lead to stillbirth. Results: Six broad categories of causes of death are accounted for, including maternal medical conditions; obstetric complications; maternal or fetal hematologic conditions; fetal genetic, structural, and karyotypic abnormalities; placental infection, fetal infection, or both; and placental pathologic findings. Isolated histologic chorioamnionitis and small for gestational age were not considered causes of death. Conclusion: A new system, Initial Causes of Fetal Death, to assign cause of death in stillbirths was developed by the SCRN investigators for use in this study but has broader applicability. Initial Causes of Fetal Death is a standardized method to assign probable and possible causes of death of stillbirths based on information routinely collected during prenatal care and the clinical evaluation of fetal death.

Original languageEnglish (US)
Pages (from-to)254-260
Number of pages7
JournalObstetrics and Gynecology
Volume116
Issue number2 PART 1
DOIs
StatePublished - Aug 2010
Externally publishedYes

Fingerprint

Stillbirth
Cause of Death
Fetal Death
Mothers
Research
Research Personnel
Pathology
Chorioamnionitis
Prenatal Care
Infection
Gestational Age
Obstetrics
Medical Records
Autopsy
Interviews

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Dudley, D. J., Goldenberg, R., Conway, D., Silver, R. M., Saade, G., Varner, M. W., ... Reddy, U. M. (2010). A new system for determining the causes of stillbirth. Obstetrics and Gynecology, 116(2 PART 1), 254-260. https://doi.org/10.1097/AOG.0b013e3181e7d975

A new system for determining the causes of stillbirth. / Dudley, Donald J.; Goldenberg, Robert; Conway, Deborah; Silver, Robert M.; Saade, George; Varner, Michael W.; Pinar, Halit; Coustan, Donald; Bukowski, Radek; Stoll, Barbara; Koch, Matthew A.; Parker, Corette B.; Reddy, Uma M.

In: Obstetrics and Gynecology, Vol. 116, No. 2 PART 1, 08.2010, p. 254-260.

Research output: Contribution to journalArticle

Dudley, DJ, Goldenberg, R, Conway, D, Silver, RM, Saade, G, Varner, MW, Pinar, H, Coustan, D, Bukowski, R, Stoll, B, Koch, MA, Parker, CB & Reddy, UM 2010, 'A new system for determining the causes of stillbirth', Obstetrics and Gynecology, vol. 116, no. 2 PART 1, pp. 254-260. https://doi.org/10.1097/AOG.0b013e3181e7d975
Dudley DJ, Goldenberg R, Conway D, Silver RM, Saade G, Varner MW et al. A new system for determining the causes of stillbirth. Obstetrics and Gynecology. 2010 Aug;116(2 PART 1):254-260. https://doi.org/10.1097/AOG.0b013e3181e7d975
Dudley, Donald J. ; Goldenberg, Robert ; Conway, Deborah ; Silver, Robert M. ; Saade, George ; Varner, Michael W. ; Pinar, Halit ; Coustan, Donald ; Bukowski, Radek ; Stoll, Barbara ; Koch, Matthew A. ; Parker, Corette B. ; Reddy, Uma M. / A new system for determining the causes of stillbirth. In: Obstetrics and Gynecology. 2010 ; Vol. 116, No. 2 PART 1. pp. 254-260.
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