A newly recognized virus associated with a fatal case of hantavirus pulmonary syndrome in Louisiana

S. P. Morzunov, H. Feldmann, C. F. Spiropoulou, V. A. Semenova, P. E. Rollin, Thomas Ksiazek, C. J. Peters, S. T. Nichol

Research output: Contribution to journalArticle

129 Citations (Scopus)

Abstract

Genetic analysis of virus detected in autopsy tissues of a fatal hantavirus pulmonary syndrome-like case in Louisiana revealed the presence of a previously unrecognized hantavirus. Nucleotide sequence analysis of PCR fragments of the complete S and M segments of the virus amplified from RNA extracted from the tissues showed the virus to be novel, differing from the closest related hantavirus, Sin Nombre virus, by approximately 30%. Both genome segments were unique, and there was no evidence of genetic reassortment with previously characterized hantaviruses. The primary rodent reservoir of Sin Nombre virus, the deer mouse Peromyscus maniculatus, is absent from Louisiana. Thus, the virus detected in Louisiana, referred to here as Bayou virus, must possess a different rodent reservoir.

Original languageEnglish (US)
Pages (from-to)1980-1983
Number of pages4
JournalJournal of Virology
Volume69
Issue number3
StatePublished - 1995
Externally publishedYes

Fingerprint

Hantavirus Pulmonary Syndrome
Sin Nombre virus
Hantavirus
Peromyscus
Viruses
viruses
Rodentia
rodents
RNA Viruses
Peromyscus maniculatus
Sequence Analysis
Autopsy
Genome
genetic techniques and protocols
necropsy
Polymerase Chain Reaction
sequence analysis
RNA
nucleotide sequences
genome

ASJC Scopus subject areas

  • Immunology

Cite this

Morzunov, S. P., Feldmann, H., Spiropoulou, C. F., Semenova, V. A., Rollin, P. E., Ksiazek, T., ... Nichol, S. T. (1995). A newly recognized virus associated with a fatal case of hantavirus pulmonary syndrome in Louisiana. Journal of Virology, 69(3), 1980-1983.

A newly recognized virus associated with a fatal case of hantavirus pulmonary syndrome in Louisiana. / Morzunov, S. P.; Feldmann, H.; Spiropoulou, C. F.; Semenova, V. A.; Rollin, P. E.; Ksiazek, Thomas; Peters, C. J.; Nichol, S. T.

In: Journal of Virology, Vol. 69, No. 3, 1995, p. 1980-1983.

Research output: Contribution to journalArticle

Morzunov, SP, Feldmann, H, Spiropoulou, CF, Semenova, VA, Rollin, PE, Ksiazek, T, Peters, CJ & Nichol, ST 1995, 'A newly recognized virus associated with a fatal case of hantavirus pulmonary syndrome in Louisiana', Journal of Virology, vol. 69, no. 3, pp. 1980-1983.
Morzunov SP, Feldmann H, Spiropoulou CF, Semenova VA, Rollin PE, Ksiazek T et al. A newly recognized virus associated with a fatal case of hantavirus pulmonary syndrome in Louisiana. Journal of Virology. 1995;69(3):1980-1983.
Morzunov, S. P. ; Feldmann, H. ; Spiropoulou, C. F. ; Semenova, V. A. ; Rollin, P. E. ; Ksiazek, Thomas ; Peters, C. J. ; Nichol, S. T. / A newly recognized virus associated with a fatal case of hantavirus pulmonary syndrome in Louisiana. In: Journal of Virology. 1995 ; Vol. 69, No. 3. pp. 1980-1983.
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