A nontoxic cholera enterotoxin (CT) analog is chimeric with regard to both epitypes of CT-B subunits, CT-B-1 and CT-B-2

Mary Boesman-Finkelstein, Johnny Peterson, Louise S. Thai, Richard A. Finkelstein

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The gene encoding a nontoxic analog, CT-2* of cholera enterotoxin (CT) with attenuating codon substitutions in the A subunit was introduced into the attenuated Vibrio cholerae classical biotype mutant candidate vaccine strain CVD103, which produces the B subunit (but nut the A subunit) of CT-1. The recombinant strain produces a chimeric nontoxic analog holotoxin protein containing both CT-B-1 and CT-B-2 subunits. This offers potential advantages over CVD103 in the induction of immunity against El Tor biotype and V. cholerae O139 strains which produce CT-B-2. The recombinant protein may also be useful in polysaccharide-protein conjugate vaccines against both O1 and O139 serovars of V. cholerae.

Original languageEnglish (US)
Pages (from-to)346-348
Number of pages3
JournalInfection and Immunity
Volume64
Issue number1
StatePublished - 1996

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Vibrio cholerae O139
Cholera Toxin
Conjugate Vaccines
Nuts
Vibrio cholerae
Recombinant Proteins
Codon
Polysaccharides
Immunity
Proteins
Vaccines
Genes

ASJC Scopus subject areas

  • Immunology

Cite this

A nontoxic cholera enterotoxin (CT) analog is chimeric with regard to both epitypes of CT-B subunits, CT-B-1 and CT-B-2. / Boesman-Finkelstein, Mary; Peterson, Johnny; Thai, Louise S.; Finkelstein, Richard A.

In: Infection and Immunity, Vol. 64, No. 1, 1996, p. 346-348.

Research output: Contribution to journalArticle

Boesman-Finkelstein, Mary ; Peterson, Johnny ; Thai, Louise S. ; Finkelstein, Richard A. / A nontoxic cholera enterotoxin (CT) analog is chimeric with regard to both epitypes of CT-B subunits, CT-B-1 and CT-B-2. In: Infection and Immunity. 1996 ; Vol. 64, No. 1. pp. 346-348.
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