TY - JOUR
T1 - A novel bronchial artery catheterization technique with preserved blood flow in an ovine model
AU - Hamahata, Atsumori
AU - Enkhbaatar, Perenlei
AU - Hiroyuki, Sakurai
AU - Morita, Naoki
AU - Nakano, Yoshimitsu
AU - Lange, Matthias
AU - Nozaki, Motohiro
AU - Traber, Lillian D.
AU - Traber, Daniel L.
N1 - Funding Information:
The authors thank Jeffrey D. Meserve for his editorial assistance. This work was supported by National Institute for General Medical Sciences grants GM66312 and GM060688 and grants 8954, 8450, and 8460 from the Shriners of North America. Corresponding author: Daniel L. Traber, Department of Anesthesiology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USA. E-mail: [email protected]
PY - 2010/3
Y1 - 2010/3
N2 - The authors devised a novel bronchial artery catheterization technique to deliver agents directly into bronchial circulation with preserved blood flow in an awake ovine model. A polyurethane catheter was inserted into bronchial artery via an incision into the 4th intercostal space. Regional blood flow of the airway was measured by fluorescent microspheres before cannulation, after cannulation, and 7 days after the operative procedure. The blood flows were also measured in a sham group (no cannulation, no ligation, n=6), cannulation group (bronchial artery cannulation, n=5), and ligation group (bronchial artery ligation, n=5) at baseline and 6 hours after burn and smoke inhalation injury. The regional blood flows decreased slightly after cannulation in proximal bronchi, but recovered after 7 days. The regional blood flow increased 10-fold after inhalation injury in bronchi of the sham group. Bronchial artery ligation significantly attenuated the increase of blood flow. However, cannulation preserved regional blood flow and did not prevent the blood flow increases after burn and smoke inhalation injury, thus constituting a novel bronchial artery catheterization technique.
AB - The authors devised a novel bronchial artery catheterization technique to deliver agents directly into bronchial circulation with preserved blood flow in an awake ovine model. A polyurethane catheter was inserted into bronchial artery via an incision into the 4th intercostal space. Regional blood flow of the airway was measured by fluorescent microspheres before cannulation, after cannulation, and 7 days after the operative procedure. The blood flows were also measured in a sham group (no cannulation, no ligation, n=6), cannulation group (bronchial artery cannulation, n=5), and ligation group (bronchial artery ligation, n=5) at baseline and 6 hours after burn and smoke inhalation injury. The regional blood flows decreased slightly after cannulation in proximal bronchi, but recovered after 7 days. The regional blood flow increased 10-fold after inhalation injury in bronchi of the sham group. Bronchial artery ligation significantly attenuated the increase of blood flow. However, cannulation preserved regional blood flow and did not prevent the blood flow increases after burn and smoke inhalation injury, thus constituting a novel bronchial artery catheterization technique.
KW - Bronchial artery
KW - Cannulation
KW - Continuous regional arterial infusion
KW - Ovine model
KW - Smoke inhalation injury
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U2 - 10.3109/01902140903287572
DO - 10.3109/01902140903287572
M3 - Article
C2 - 20334606
AN - SCOPUS:77950202874
SN - 0190-2148
VL - 36
SP - 183
EP - 189
JO - Experimental Lung Research
JF - Experimental Lung Research
IS - 3
ER -