A novel bronchial artery catheterization technique with preserved blood flow in an ovine model

Atsumori Hamahata, Perenlei Enkhbaatar, Sakurai Hiroyuki, Naoki Morita, Yoshimitsu Nakano, Matthias Lange, Motohiro Nozaki, Lillian D. Traber, Daniel L. Traber

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The authors devised a novel bronchial artery catheterization technique to deliver agents directly into bronchial circulation with preserved blood flow in an awake ovine model. A polyurethane catheter was inserted into bronchial artery via an incision into the 4th intercostal space. Regional blood flow of the airway was measured by fluorescent microspheres before cannulation, after cannulation, and 7 days after the operative procedure. The blood flows were also measured in a sham group (no cannulation, no ligation, n=6), cannulation group (bronchial artery cannulation, n=5), and ligation group (bronchial artery ligation, n=5) at baseline and 6 hours after burn and smoke inhalation injury. The regional blood flows decreased slightly after cannulation in proximal bronchi, but recovered after 7 days. The regional blood flow increased 10-fold after inhalation injury in bronchi of the sham group. Bronchial artery ligation significantly attenuated the increase of blood flow. However, cannulation preserved regional blood flow and did not prevent the blood flow increases after burn and smoke inhalation injury, thus constituting a novel bronchial artery catheterization technique.

Original languageEnglish (US)
Pages (from-to)183-189
Number of pages7
JournalExperimental Lung Research
Volume36
Issue number3
DOIs
StatePublished - Mar 2010

Fingerprint

Peripheral Catheterization
Bronchial Arteries
Catheterization
Sheep
Blood
Regional Blood Flow
Ligation
Smoke Inhalation Injury
Bronchi
Smoke
Polyurethanes
Operative Surgical Procedures
Catheters
Microspheres
Inhalation

Keywords

  • Bronchial artery
  • Cannulation
  • Continuous regional arterial infusion
  • Ovine model
  • Smoke inhalation injury

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Molecular Biology
  • Clinical Biochemistry

Cite this

A novel bronchial artery catheterization technique with preserved blood flow in an ovine model. / Hamahata, Atsumori; Enkhbaatar, Perenlei; Hiroyuki, Sakurai; Morita, Naoki; Nakano, Yoshimitsu; Lange, Matthias; Nozaki, Motohiro; Traber, Lillian D.; Traber, Daniel L.

In: Experimental Lung Research, Vol. 36, No. 3, 03.2010, p. 183-189.

Research output: Contribution to journalArticle

Hamahata, A, Enkhbaatar, P, Hiroyuki, S, Morita, N, Nakano, Y, Lange, M, Nozaki, M, Traber, LD & Traber, DL 2010, 'A novel bronchial artery catheterization technique with preserved blood flow in an ovine model', Experimental Lung Research, vol. 36, no. 3, pp. 183-189. https://doi.org/10.3109/01902140903287572
Hamahata, Atsumori ; Enkhbaatar, Perenlei ; Hiroyuki, Sakurai ; Morita, Naoki ; Nakano, Yoshimitsu ; Lange, Matthias ; Nozaki, Motohiro ; Traber, Lillian D. ; Traber, Daniel L. / A novel bronchial artery catheterization technique with preserved blood flow in an ovine model. In: Experimental Lung Research. 2010 ; Vol. 36, No. 3. pp. 183-189.
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