A novel endogenous indole protects rodent mitochondria and extends rotifer lifespan

Burkhard Poeggeler, Kumar Sambamurti, Sandra L. Siedlak, George Perry, Mark A. Smith, Miguel Pappolla

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Aging is a multi-factorial process, however, it is generally accepted that reactive oxygen species (ROS) are significant contributors. Mitochondria are important players in the aging process because they produce most of the cellular ROS. Despite the strength of the free-radical hypothesis, the use of free radical scavengers to delay aging has generated mixed results in vertebrate models, and clinical evidence of efficacy is lacking. This is in part due to the production of pro-oxidant metabolites by many antioxidants while scavenging ROS, which counteract their potentially beneficial effects. As such, a more effective approach is to enhance mitochondrial metabolism by reducing electron leakage with attendant reduction of ROS generation. Here, we report on the actions of a novel endogenous indole derivative, indolepropionamide (IPAM), which is similar in structure to melatonin. Our results suggest that IPAM binds to the rate-limiting component of oxidative phosphorylation in complex I of the respiratory chain and acts as a stabilizer of energy metabolism, thereby reducing ROS production. IPAM reversed the age-dependent decline of mitochondrial energetic capacity and increased rotifer lifespan, and it may, in fact, constitute a novel endogenous anti-aging substance of physiological importance.

Original languageEnglish
Article numbere10206
JournalPLoS One
Volume5
Issue number4
DOIs
StatePublished - 2010
Externally publishedYes

Fingerprint

Mitochondria
indoles
Rotifera
reactive oxygen species
Rodentia
Reactive Oxygen Species
mitochondria
rodents
Aging of materials
NADH dehydrogenase (ubiquinone)
oxidative phosphorylation
free radical scavengers
electron transport chain
melatonin
Free Radical Scavengers
oxidants
energy metabolism
Oxidative Phosphorylation
Scavenging
Melatonin

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

A novel endogenous indole protects rodent mitochondria and extends rotifer lifespan. / Poeggeler, Burkhard; Sambamurti, Kumar; Siedlak, Sandra L.; Perry, George; Smith, Mark A.; Pappolla, Miguel.

In: PLoS One, Vol. 5, No. 4, e10206, 2010.

Research output: Contribution to journalArticle

Poeggeler, Burkhard ; Sambamurti, Kumar ; Siedlak, Sandra L. ; Perry, George ; Smith, Mark A. ; Pappolla, Miguel. / A novel endogenous indole protects rodent mitochondria and extends rotifer lifespan. In: PLoS One. 2010 ; Vol. 5, No. 4.
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