A novel mutation in the switch 3 region of G(s)α in a patient with albright hereditary osteodystrophy impairs GDP binding and receptor activation

Keyphrases

• Receptor Activation 100%
• Guanosine 100%
• Novel mutation 100%
• Albright Hereditary Osteodystrophy 100%
• GDP Binding 100%
• Trypsin 50%
• Arginine 50%
• Adenylyl Cyclase 50%
• Helical Domain 50%
• GDP Release 50%
• Obesity 25%
• Complementary DNA (cDNA) 25%
• MRNA Expression 25%
• Denaturation 25%
• Quantitative PCR 25%
• Escherichia Coli 25%
• Biochemical Properties 25%
• Reaction Studies 25%
• Thermal Stability 25%
• Mutant Protein 25%
• Thermolabile 25%
• Tryptophan 25%
• Isoproterenol 25%
• Conserved Residues 25%
• Gradient Analysis 25%
• Sucrose Gradient 25%
• Protection Assay 25%
• In Vitro Translation 25%
• Mutant Alleles 25%
• Translation Product 25%
• Erythrocyte Membrane 25%
• Apparent Rate Constant 25%
• High Temperature 25%
• Inactivating mutation 25%
• Inactive State 25%
• Aluminum Chloride 25%
• Skeletal Abnormalities 25%
• GTPase Domain 25%

Biochemistry, Genetics and Molecular Biology

• Guanosine 100%
• Adenylate Cyclase 50%
• Wild Type 50%
• Arginine 50%
• Transcription 25%
• Crystal Structure 25%
• Sucrose 25%
• Escherichia coli 25%
• GTPase 25%
• Mutant Protein 25%
• Allele 25%
• Density Gradient Centrifugation 25%
• Denaturation 25%
• Erythrocyte Membrane 25%
• Messenger RNA 25%
• Alanine 25%
• Tryptophan 25%
• Reverse Transcription Polymerase Chain Reaction 25%
• Isoprenaline 25%