A novel vasodilatory peptide from the salivary glands of the sand fly Lutzomyia longipalpis

José M.C. Ribeiro, André Vachereau, Govind B. Modi, Robert B. Tesh

Research output: Contribution to journalArticlepeer-review

78 Scopus citations

Abstract

Salivary gland lysates of the sand fly Lutzomyia longipalpis contain a potent vasodilator that aids the fly to feed on the blood of its vertebrate hosts. Chromatographic analysis, antibody reactivity, and data obtained from bioassays of the salivary erythema-inducing factor indicate striking similarity with human calcitonin gene-related peptide. The erythema-inducing factor is, however, at least one order of magnitude more potent than calcitonin gene-related peptide.

Original languageEnglish (US)
Pages (from-to)212-214
Number of pages3
JournalScience
Volume243
Issue number4888
DOIs
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • General

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