A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study

Nikos Papadimitriou, David Muller, Piet A. van den Brandt, Milan Geybels, Chirag J. Patel, Marc J. Gunter, David S. Lopez, Timothy J. Key, Aurora Perez-Cornago, Pietro Ferrari, Paolo Vineis, Elisabete Weiderpass, Heiner Boeing, Antonio Agudo, María José Sánchez, Kim Overvad, Tilman Kühn, Renee T. Fortner, Domenico Palli, Isabel DrakeAnders Bjartell, Carmen Santiuste, Bas H. Bueno-de-Mesquita, Vittorio Krogh, Anne Tjønneland, Dorthe Furstrand Lauritzen, Aurelio Barricarte Gurrea, José Ramón Quirós, Pär Stattin, Antonia Trichopoulou, Georgia Martimianaki, Anna Karakatsani, Elin Thysell, Ingegerd Johansson, Fulvio Ricceri, Rosario Tumino, Nerea Larrañaga, Kay Tee Khaw, Elio Riboli, Ioanna Tzoulaki, Konstantinos K. Tsilidis

Research output: Contribution to journalArticle

Abstract

Purpose: The evidence from the literature regarding the association of dietary factors and risk of prostate cancer is inconclusive. Methods: A nutrient-wide association study was conducted to systematically and comprehensively evaluate the associations between 92 foods or nutrients and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cox proportional hazard regression models adjusted for total energy intake, smoking status, body mass index, physical activity, diabetes and education were used to estimate hazard ratios and 95% confidence intervals for standardized dietary intakes. As in genome-wide association studies, correction for multiple comparisons was applied using the false discovery rate (FDR < 5%) method and suggested results were replicated in an independent cohort, the Netherlands Cohort Study (NLCS). Results: A total of 5916 and 3842 incident cases of prostate cancer were diagnosed during a mean follow-up of 14 and 20 years in EPIC and NLCS, respectively. None of the dietary factors was associated with the risk of total prostate cancer in EPIC (minimum FDR-corrected P, 0.37). Null associations were also observed by disease stage, grade and fatality, except for positive associations observed for intake of dry cakes/biscuits with low-grade and butter with aggressive prostate cancer, respectively, out of which the intake of dry cakes/biscuits was replicated in the NLCS. Conclusions: Our findings provide little support for an association for the majority of the 92 examined dietary factors and risk of prostate cancer. The association of dry cakes/biscuits with low-grade prostate cancer warrants further replication given the scarcity in the literature.

Original languageEnglish (US)
JournalEuropean Journal of Nutrition
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Netherlands
Prostatic Neoplasms
Cohort Studies
Food
Neoplasms
Butter
Physical Education and Training
Genome-Wide Association Study
Energy Intake
Proportional Hazards Models
Body Mass Index
Smoking
Confidence Intervals

Keywords

  • Cohort study
  • Diet
  • Epidemiology
  • Nutrition
  • Prostate cancer

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study. / Papadimitriou, Nikos; Muller, David; van den Brandt, Piet A.; Geybels, Milan; Patel, Chirag J.; Gunter, Marc J.; Lopez, David S.; Key, Timothy J.; Perez-Cornago, Aurora; Ferrari, Pietro; Vineis, Paolo; Weiderpass, Elisabete; Boeing, Heiner; Agudo, Antonio; Sánchez, María José; Overvad, Kim; Kühn, Tilman; Fortner, Renee T.; Palli, Domenico; Drake, Isabel; Bjartell, Anders; Santiuste, Carmen; Bueno-de-Mesquita, Bas H.; Krogh, Vittorio; Tjønneland, Anne; Lauritzen, Dorthe Furstrand; Gurrea, Aurelio Barricarte; Quirós, José Ramón; Stattin, Pär; Trichopoulou, Antonia; Martimianaki, Georgia; Karakatsani, Anna; Thysell, Elin; Johansson, Ingegerd; Ricceri, Fulvio; Tumino, Rosario; Larrañaga, Nerea; Khaw, Kay Tee; Riboli, Elio; Tzoulaki, Ioanna; Tsilidis, Konstantinos K.

In: European Journal of Nutrition, 01.01.2019.

Research output: Contribution to journalArticle

Papadimitriou, N, Muller, D, van den Brandt, PA, Geybels, M, Patel, CJ, Gunter, MJ, Lopez, DS, Key, TJ, Perez-Cornago, A, Ferrari, P, Vineis, P, Weiderpass, E, Boeing, H, Agudo, A, Sánchez, MJ, Overvad, K, Kühn, T, Fortner, RT, Palli, D, Drake, I, Bjartell, A, Santiuste, C, Bueno-de-Mesquita, BH, Krogh, V, Tjønneland, A, Lauritzen, DF, Gurrea, AB, Quirós, JR, Stattin, P, Trichopoulou, A, Martimianaki, G, Karakatsani, A, Thysell, E, Johansson, I, Ricceri, F, Tumino, R, Larrañaga, N, Khaw, KT, Riboli, E, Tzoulaki, I & Tsilidis, KK 2019, 'A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study', European Journal of Nutrition. https://doi.org/10.1007/s00394-019-02132-z
Papadimitriou, Nikos ; Muller, David ; van den Brandt, Piet A. ; Geybels, Milan ; Patel, Chirag J. ; Gunter, Marc J. ; Lopez, David S. ; Key, Timothy J. ; Perez-Cornago, Aurora ; Ferrari, Pietro ; Vineis, Paolo ; Weiderpass, Elisabete ; Boeing, Heiner ; Agudo, Antonio ; Sánchez, María José ; Overvad, Kim ; Kühn, Tilman ; Fortner, Renee T. ; Palli, Domenico ; Drake, Isabel ; Bjartell, Anders ; Santiuste, Carmen ; Bueno-de-Mesquita, Bas H. ; Krogh, Vittorio ; Tjønneland, Anne ; Lauritzen, Dorthe Furstrand ; Gurrea, Aurelio Barricarte ; Quirós, José Ramón ; Stattin, Pär ; Trichopoulou, Antonia ; Martimianaki, Georgia ; Karakatsani, Anna ; Thysell, Elin ; Johansson, Ingegerd ; Ricceri, Fulvio ; Tumino, Rosario ; Larrañaga, Nerea ; Khaw, Kay Tee ; Riboli, Elio ; Tzoulaki, Ioanna ; Tsilidis, Konstantinos K. / A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study. In: European Journal of Nutrition. 2019.
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abstract = "Purpose: The evidence from the literature regarding the association of dietary factors and risk of prostate cancer is inconclusive. Methods: A nutrient-wide association study was conducted to systematically and comprehensively evaluate the associations between 92 foods or nutrients and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cox proportional hazard regression models adjusted for total energy intake, smoking status, body mass index, physical activity, diabetes and education were used to estimate hazard ratios and 95{\%} confidence intervals for standardized dietary intakes. As in genome-wide association studies, correction for multiple comparisons was applied using the false discovery rate (FDR < 5{\%}) method and suggested results were replicated in an independent cohort, the Netherlands Cohort Study (NLCS). Results: A total of 5916 and 3842 incident cases of prostate cancer were diagnosed during a mean follow-up of 14 and 20 years in EPIC and NLCS, respectively. None of the dietary factors was associated with the risk of total prostate cancer in EPIC (minimum FDR-corrected P, 0.37). Null associations were also observed by disease stage, grade and fatality, except for positive associations observed for intake of dry cakes/biscuits with low-grade and butter with aggressive prostate cancer, respectively, out of which the intake of dry cakes/biscuits was replicated in the NLCS. Conclusions: Our findings provide little support for an association for the majority of the 92 examined dietary factors and risk of prostate cancer. The association of dry cakes/biscuits with low-grade prostate cancer warrants further replication given the scarcity in the literature.",
keywords = "Cohort study, Diet, Epidemiology, Nutrition, Prostate cancer",
author = "Nikos Papadimitriou and David Muller and {van den Brandt}, {Piet A.} and Milan Geybels and Patel, {Chirag J.} and Gunter, {Marc J.} and Lopez, {David S.} and Key, {Timothy J.} and Aurora Perez-Cornago and Pietro Ferrari and Paolo Vineis and Elisabete Weiderpass and Heiner Boeing and Antonio Agudo and S{\'a}nchez, {Mar{\'i}a Jos{\'e}} and Kim Overvad and Tilman K{\"u}hn and Fortner, {Renee T.} and Domenico Palli and Isabel Drake and Anders Bjartell and Carmen Santiuste and Bueno-de-Mesquita, {Bas H.} and Vittorio Krogh and Anne Tj{\o}nneland and Lauritzen, {Dorthe Furstrand} and Gurrea, {Aurelio Barricarte} and Quir{\'o}s, {Jos{\'e} Ram{\'o}n} and P{\"a}r Stattin and Antonia Trichopoulou and Georgia Martimianaki and Anna Karakatsani and Elin Thysell and Ingegerd Johansson and Fulvio Ricceri and Rosario Tumino and Nerea Larra{\~n}aga and Khaw, {Kay Tee} and Elio Riboli and Ioanna Tzoulaki and Tsilidis, {Konstantinos K.}",
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T1 - A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study

AU - Papadimitriou, Nikos

AU - Muller, David

AU - van den Brandt, Piet A.

AU - Geybels, Milan

AU - Patel, Chirag J.

AU - Gunter, Marc J.

AU - Lopez, David S.

AU - Key, Timothy J.

AU - Perez-Cornago, Aurora

AU - Ferrari, Pietro

AU - Vineis, Paolo

AU - Weiderpass, Elisabete

AU - Boeing, Heiner

AU - Agudo, Antonio

AU - Sánchez, María José

AU - Overvad, Kim

AU - Kühn, Tilman

AU - Fortner, Renee T.

AU - Palli, Domenico

AU - Drake, Isabel

AU - Bjartell, Anders

AU - Santiuste, Carmen

AU - Bueno-de-Mesquita, Bas H.

AU - Krogh, Vittorio

AU - Tjønneland, Anne

AU - Lauritzen, Dorthe Furstrand

AU - Gurrea, Aurelio Barricarte

AU - Quirós, José Ramón

AU - Stattin, Pär

AU - Trichopoulou, Antonia

AU - Martimianaki, Georgia

AU - Karakatsani, Anna

AU - Thysell, Elin

AU - Johansson, Ingegerd

AU - Ricceri, Fulvio

AU - Tumino, Rosario

AU - Larrañaga, Nerea

AU - Khaw, Kay Tee

AU - Riboli, Elio

AU - Tzoulaki, Ioanna

AU - Tsilidis, Konstantinos K.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Purpose: The evidence from the literature regarding the association of dietary factors and risk of prostate cancer is inconclusive. Methods: A nutrient-wide association study was conducted to systematically and comprehensively evaluate the associations between 92 foods or nutrients and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cox proportional hazard regression models adjusted for total energy intake, smoking status, body mass index, physical activity, diabetes and education were used to estimate hazard ratios and 95% confidence intervals for standardized dietary intakes. As in genome-wide association studies, correction for multiple comparisons was applied using the false discovery rate (FDR < 5%) method and suggested results were replicated in an independent cohort, the Netherlands Cohort Study (NLCS). Results: A total of 5916 and 3842 incident cases of prostate cancer were diagnosed during a mean follow-up of 14 and 20 years in EPIC and NLCS, respectively. None of the dietary factors was associated with the risk of total prostate cancer in EPIC (minimum FDR-corrected P, 0.37). Null associations were also observed by disease stage, grade and fatality, except for positive associations observed for intake of dry cakes/biscuits with low-grade and butter with aggressive prostate cancer, respectively, out of which the intake of dry cakes/biscuits was replicated in the NLCS. Conclusions: Our findings provide little support for an association for the majority of the 92 examined dietary factors and risk of prostate cancer. The association of dry cakes/biscuits with low-grade prostate cancer warrants further replication given the scarcity in the literature.

AB - Purpose: The evidence from the literature regarding the association of dietary factors and risk of prostate cancer is inconclusive. Methods: A nutrient-wide association study was conducted to systematically and comprehensively evaluate the associations between 92 foods or nutrients and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cox proportional hazard regression models adjusted for total energy intake, smoking status, body mass index, physical activity, diabetes and education were used to estimate hazard ratios and 95% confidence intervals for standardized dietary intakes. As in genome-wide association studies, correction for multiple comparisons was applied using the false discovery rate (FDR < 5%) method and suggested results were replicated in an independent cohort, the Netherlands Cohort Study (NLCS). Results: A total of 5916 and 3842 incident cases of prostate cancer were diagnosed during a mean follow-up of 14 and 20 years in EPIC and NLCS, respectively. None of the dietary factors was associated with the risk of total prostate cancer in EPIC (minimum FDR-corrected P, 0.37). Null associations were also observed by disease stage, grade and fatality, except for positive associations observed for intake of dry cakes/biscuits with low-grade and butter with aggressive prostate cancer, respectively, out of which the intake of dry cakes/biscuits was replicated in the NLCS. Conclusions: Our findings provide little support for an association for the majority of the 92 examined dietary factors and risk of prostate cancer. The association of dry cakes/biscuits with low-grade prostate cancer warrants further replication given the scarcity in the literature.

KW - Cohort study

KW - Diet

KW - Epidemiology

KW - Nutrition

KW - Prostate cancer

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U2 - 10.1007/s00394-019-02132-z

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