A pattern of cerebral perfusion anomalies between Major Depressive Disorder and Hashimoto Thyroiditis

Maria C. Hardoy, Mariangela Cadeddu, Alessandra Serra, Maria F. Moro, Gioia Mura, Gisa Mellino, Krishna M. Bhat, Gianmarco Altoé, Paolo Usai, Mario Piga, Mauro G. Carta

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background: This study aims to evaluate relationship between three different clinical conditions: Major Depressive Disorders (MDD), Hashimoto Thyroiditis (HT) and reduction in regional Cerebral Blood Flow (rCBF) in order to explore the possibility that patients with HT and MDD have specific pattern(s) of cerebral perfusion.Methods: Design: Analysis of data derived from two separate data banks.Sample: 54 subjects, 32 with HT (29 women, mean age 38.8 ± 13.9); 22 without HT (19 women, mean age 36.5 ± 12.25).Assessment: Psychiatric diagnosis was carried out by Simplified Composite International Diagnostic Interview (CIDIS) using DSM-IV categories; cerebral perfusion was measured by 99 mTc-ECD SPECT. Statistical analysis was done through logistic regression.Results: MDD appears to be associated with left frontal hypoperfusion, left temporal hypoperfusion, diffuse hypoperfusion and parietal perfusion asymmetry. A statistically significant association between parietal perfusion asymmetry and MDD was found only in the HT group.Conclusion: In HT, MDD is characterized by a parietal flow asymmetry. However, the specificity of rCBF in MDD with HT should be confirmed in a control sample with consideration for other health conditions. Moreover, this should be investigated with a longitudinally designed study in order to determine a possible pathogenic cause. Future studies with a much larger sample size should clarify whether a particular perfusion pattern is associated with a specific course or symptom cluster of MDD.

Original languageEnglish (US)
Article number148
JournalBMC Psychiatry
Volume11
DOIs
StatePublished - Sep 13 2011

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Hashimoto Disease
Major Depressive Disorder
Perfusion
Cerebrovascular Circulation
Regional Blood Flow
Single-Photon Emission-Computed Tomography
Mental Disorders
Diagnostic and Statistical Manual of Mental Disorders
Sample Size
Logistic Models
Databases
Interviews
Health

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Hardoy, M. C., Cadeddu, M., Serra, A., Moro, M. F., Mura, G., Mellino, G., ... Carta, M. G. (2011). A pattern of cerebral perfusion anomalies between Major Depressive Disorder and Hashimoto Thyroiditis. BMC Psychiatry, 11, [148]. https://doi.org/10.1186/1471-244X-11-148

A pattern of cerebral perfusion anomalies between Major Depressive Disorder and Hashimoto Thyroiditis. / Hardoy, Maria C.; Cadeddu, Mariangela; Serra, Alessandra; Moro, Maria F.; Mura, Gioia; Mellino, Gisa; Bhat, Krishna M.; Altoé, Gianmarco; Usai, Paolo; Piga, Mario; Carta, Mauro G.

In: BMC Psychiatry, Vol. 11, 148, 13.09.2011.

Research output: Contribution to journalArticle

Hardoy, MC, Cadeddu, M, Serra, A, Moro, MF, Mura, G, Mellino, G, Bhat, KM, Altoé, G, Usai, P, Piga, M & Carta, MG 2011, 'A pattern of cerebral perfusion anomalies between Major Depressive Disorder and Hashimoto Thyroiditis', BMC Psychiatry, vol. 11, 148. https://doi.org/10.1186/1471-244X-11-148
Hardoy, Maria C. ; Cadeddu, Mariangela ; Serra, Alessandra ; Moro, Maria F. ; Mura, Gioia ; Mellino, Gisa ; Bhat, Krishna M. ; Altoé, Gianmarco ; Usai, Paolo ; Piga, Mario ; Carta, Mauro G. / A pattern of cerebral perfusion anomalies between Major Depressive Disorder and Hashimoto Thyroiditis. In: BMC Psychiatry. 2011 ; Vol. 11.
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