A percutaneous needle biopsy technique for sampling the supraclavicular brown adipose tissue depot of humans

M. Chondronikola, P. Annamalai, Tony Chao, Craig Porter, M. K. Saraf, F. Cesani, L. S. Sidossis

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Brown adipose tissue (BAT) has been proposed as a potential target tissue against obesity and its related metabolic complications. Although the molecular and functional characteristics of BAT have been intensively studied in rodents, only a few studies have used human BAT specimens due to the difficulty of sampling human BAT deposits. We established a novel positron emission tomography and computed tomography-guided Bergström needle biopsy technique to acquire human BAT specimens from the supraclavicular area in human subjects. Forty-three biopsies were performed on 23 participants. The procedure was tolerated well by the majority of participants. No major complications were noted. Numbness (9.6%) and hematoma (2.3%) were the two minor complications noted, which fully resolved. Thus, the proposed biopsy technique can be considered safe with only minimal risk of adverse events. Adoption of the proposed method is expected to increase the sampling of the supraclavicular BAT depot for research purposes so as to augment the scientific knowledge of the biology of human BAT.International Journal of Obesity advance online publication, 9 June 2015; doi:10.1038/ijo.2015.76.

Original languageEnglish (US)
JournalInternational Journal of Obesity
DOIs
StateAccepted/In press - Apr 29 2015

Fingerprint

Brown Adipose Tissue
Needle Biopsy
Obesity
Biopsy
Hypesthesia
Hematoma
Publications
Rodentia
Research

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism

Cite this

Chondronikola, M., Annamalai, P., Chao, T., Porter, C., Saraf, M. K., Cesani, F., & Sidossis, L. S. (Accepted/In press). A percutaneous needle biopsy technique for sampling the supraclavicular brown adipose tissue depot of humans. International Journal of Obesity. https://doi.org/10.1038/ijo.2015.76

A percutaneous needle biopsy technique for sampling the supraclavicular brown adipose tissue depot of humans. / Chondronikola, M.; Annamalai, P.; Chao, Tony; Porter, Craig; Saraf, M. K.; Cesani, F.; Sidossis, L. S.

In: International Journal of Obesity, 29.04.2015.

Research output: Contribution to journalArticle

Chondronikola, M. ; Annamalai, P. ; Chao, Tony ; Porter, Craig ; Saraf, M. K. ; Cesani, F. ; Sidossis, L. S. / A percutaneous needle biopsy technique for sampling the supraclavicular brown adipose tissue depot of humans. In: International Journal of Obesity. 2015.
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