A phase 2 study of bortezomib in combination with ifosfamide/vinorelbine in paediatric patients and young adults with refractory/recurrent Hodgkin lymphoma

A Children's Oncology Group study

Terzah M. Horton, Richard A. Drachtman, Lu Chen, Peter D. Cole, Kathleen Mccarten, Stephan Voss, Robert P. Guillerman, Allen Buxton, Scott C. Howard, Shirley M. Hogan, Andrea M. Sheehan, Dolores López-Terrada, Matthew Mrazek, Neeraj Agrawal, Meng Fen Wu, Hao Liu, Pedro A. De Alarcon, Tanya M. Trippet, Cindy L. Schwartz

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

A Children's Oncology Group clinical trial aimed to determine if bortezomib (B) increased the efficacy of ifosfamide and vinorelbine (IV) in paediatric Hodgkin lymphoma (HL). This study enrolled 26 relapsed HL patients (

Original languageEnglish (US)
Pages (from-to)118-122
Number of pages5
JournalBritish Journal of Haematology
Volume170
Issue number1
DOIs
StatePublished - Jul 1 2015
Externally publishedYes

Fingerprint

Ifosfamide
Hodgkin Disease
Young Adult
Pediatrics
Clinical Trials
vinorelbine
Bortezomib

Keywords

  • Childhood haematological malignancies
  • Clinical trials
  • NF-κB
  • Paediatric oncology

ASJC Scopus subject areas

  • Medicine(all)
  • Hematology

Cite this

A phase 2 study of bortezomib in combination with ifosfamide/vinorelbine in paediatric patients and young adults with refractory/recurrent Hodgkin lymphoma : A Children's Oncology Group study. / Horton, Terzah M.; Drachtman, Richard A.; Chen, Lu; Cole, Peter D.; Mccarten, Kathleen; Voss, Stephan; Guillerman, Robert P.; Buxton, Allen; Howard, Scott C.; Hogan, Shirley M.; Sheehan, Andrea M.; López-Terrada, Dolores; Mrazek, Matthew; Agrawal, Neeraj; Wu, Meng Fen; Liu, Hao; De Alarcon, Pedro A.; Trippet, Tanya M.; Schwartz, Cindy L.

In: British Journal of Haematology, Vol. 170, No. 1, 01.07.2015, p. 118-122.

Research output: Contribution to journalArticle

Horton, TM, Drachtman, RA, Chen, L, Cole, PD, Mccarten, K, Voss, S, Guillerman, RP, Buxton, A, Howard, SC, Hogan, SM, Sheehan, AM, López-Terrada, D, Mrazek, M, Agrawal, N, Wu, MF, Liu, H, De Alarcon, PA, Trippet, TM & Schwartz, CL 2015, 'A phase 2 study of bortezomib in combination with ifosfamide/vinorelbine in paediatric patients and young adults with refractory/recurrent Hodgkin lymphoma: A Children's Oncology Group study', British Journal of Haematology, vol. 170, no. 1, pp. 118-122. https://doi.org/10.1111/bjh.13388
Horton, Terzah M. ; Drachtman, Richard A. ; Chen, Lu ; Cole, Peter D. ; Mccarten, Kathleen ; Voss, Stephan ; Guillerman, Robert P. ; Buxton, Allen ; Howard, Scott C. ; Hogan, Shirley M. ; Sheehan, Andrea M. ; López-Terrada, Dolores ; Mrazek, Matthew ; Agrawal, Neeraj ; Wu, Meng Fen ; Liu, Hao ; De Alarcon, Pedro A. ; Trippet, Tanya M. ; Schwartz, Cindy L. / A phase 2 study of bortezomib in combination with ifosfamide/vinorelbine in paediatric patients and young adults with refractory/recurrent Hodgkin lymphoma : A Children's Oncology Group study. In: British Journal of Haematology. 2015 ; Vol. 170, No. 1. pp. 118-122.
@article{360780f26d4d471c85a07f76ad5c1b0c,
title = "A phase 2 study of bortezomib in combination with ifosfamide/vinorelbine in paediatric patients and young adults with refractory/recurrent Hodgkin lymphoma: A Children's Oncology Group study",
abstract = "A Children's Oncology Group clinical trial aimed to determine if bortezomib (B) increased the efficacy of ifosfamide and vinorelbine (IV) in paediatric Hodgkin lymphoma (HL). This study enrolled 26 relapsed HL patients (",
keywords = "Childhood haematological malignancies, Clinical trials, NF-κB, Paediatric oncology",
author = "Horton, {Terzah M.} and Drachtman, {Richard A.} and Lu Chen and Cole, {Peter D.} and Kathleen Mccarten and Stephan Voss and Guillerman, {Robert P.} and Allen Buxton and Howard, {Scott C.} and Hogan, {Shirley M.} and Sheehan, {Andrea M.} and Dolores L{\'o}pez-Terrada and Matthew Mrazek and Neeraj Agrawal and Wu, {Meng Fen} and Hao Liu and {De Alarcon}, {Pedro A.} and Trippet, {Tanya M.} and Schwartz, {Cindy L.}",
year = "2015",
month = "7",
day = "1",
doi = "10.1111/bjh.13388",
language = "English (US)",
volume = "170",
pages = "118--122",
journal = "British Journal of Haematology",
issn = "0007-1048",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - A phase 2 study of bortezomib in combination with ifosfamide/vinorelbine in paediatric patients and young adults with refractory/recurrent Hodgkin lymphoma

T2 - A Children's Oncology Group study

AU - Horton, Terzah M.

AU - Drachtman, Richard A.

AU - Chen, Lu

AU - Cole, Peter D.

AU - Mccarten, Kathleen

AU - Voss, Stephan

AU - Guillerman, Robert P.

AU - Buxton, Allen

AU - Howard, Scott C.

AU - Hogan, Shirley M.

AU - Sheehan, Andrea M.

AU - López-Terrada, Dolores

AU - Mrazek, Matthew

AU - Agrawal, Neeraj

AU - Wu, Meng Fen

AU - Liu, Hao

AU - De Alarcon, Pedro A.

AU - Trippet, Tanya M.

AU - Schwartz, Cindy L.

PY - 2015/7/1

Y1 - 2015/7/1

N2 - A Children's Oncology Group clinical trial aimed to determine if bortezomib (B) increased the efficacy of ifosfamide and vinorelbine (IV) in paediatric Hodgkin lymphoma (HL). This study enrolled 26 relapsed HL patients (

AB - A Children's Oncology Group clinical trial aimed to determine if bortezomib (B) increased the efficacy of ifosfamide and vinorelbine (IV) in paediatric Hodgkin lymphoma (HL). This study enrolled 26 relapsed HL patients (

KW - Childhood haematological malignancies

KW - Clinical trials

KW - NF-κB

KW - Paediatric oncology

UR - http://www.scopus.com/inward/record.url?scp=84931563104&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84931563104&partnerID=8YFLogxK

U2 - 10.1111/bjh.13388

DO - 10.1111/bjh.13388

M3 - Article

VL - 170

SP - 118

EP - 122

JO - British Journal of Haematology

JF - British Journal of Haematology

SN - 0007-1048

IS - 1

ER -