A phase 2 study of bortezomib in combination with ifosfamide/vinorelbine in paediatric patients and young adults with refractory/recurrent Hodgkin lymphoma: A Children's Oncology Group study

Terzah M. Horton, Richard A. Drachtman, Lu Chen, Peter D. Cole, Kathleen Mccarten, Stephan Voss, Robert P. Guillerman, Allen Buxton, Scott C. Howard, Shirley M. Hogan, Andrea M. Sheehan, Dolores López-Terrada, Matthew Mrazek, Neeraj Agrawal, Meng Fen Wu, Hao Liu, Pedro A. De Alarcon, Tanya M. Trippet, Cindy L. Schwartz

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

A Children's Oncology Group clinical trial aimed to determine if bortezomib (B) increased the efficacy of ifosfamide and vinorelbine (IV) in paediatric Hodgkin lymphoma (HL). This study enrolled 26 relapsed HL patients (

Original languageEnglish (US)
Pages (from-to)118-122
Number of pages5
JournalBritish Journal of Haematology
Volume170
Issue number1
DOIs
StatePublished - Jul 1 2015
Externally publishedYes

Keywords

  • Childhood haematological malignancies
  • Clinical trials
  • NF-κB
  • Paediatric oncology

ASJC Scopus subject areas

  • Medicine(all)
  • Hematology

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    Horton, T. M., Drachtman, R. A., Chen, L., Cole, P. D., Mccarten, K., Voss, S., Guillerman, R. P., Buxton, A., Howard, S. C., Hogan, S. M., Sheehan, A. M., López-Terrada, D., Mrazek, M., Agrawal, N., Wu, M. F., Liu, H., De Alarcon, P. A., Trippet, T. M., & Schwartz, C. L. (2015). A phase 2 study of bortezomib in combination with ifosfamide/vinorelbine in paediatric patients and young adults with refractory/recurrent Hodgkin lymphoma: A Children's Oncology Group study. British Journal of Haematology, 170(1), 118-122. https://doi.org/10.1111/bjh.13388