A phase I/II study of altered fractionated imrt alone for intermediate t-stage oropharyngeal carcinoma

G. Brandon Gunn, Eugene J. Endres, Brent Parker, Maria Pia Sormani, Giuseppe Sanguineti

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Background and Purpose: To prospectively assess the feasibility and efficacy of an accelerated and hyperfractionated intensity- modulated radiation therapy (IMRT) schedule for intermediate T-stage oropharyngeal cancer. Patients and Methods: Patients with T3 or unfavorable T2 oropharyngeal squamous cell carcinoma were eligible; a three-dose level simultaneous integrated boost IMRT strategy was used, delivering 78, 69, and 60 Gy to gross disease, high-risk and low-risk target areas, respectively, in 60 twice daily fractions over 6 weeks. No sequential/concomitant systemic treatment or up-front radical surgery was allowed. Median follow-up is 41.7 months (range: 3.5-80.8 months). Results: 25 patients were treated from 11/2002 to 11/2005. 92% of the individual fractions were delivered as scheduled. Grade 3 mucosal and skin toxicity was 100% and 72%, respectively, none of which persisted beyond 12 weeks; a percutaneous endoscopic gastrostomy tube was temporarily placed in 60% of patients. The estimated locoregional progression-free, distant metastases-free, and overall survival rates at 3 years were 86.3% ± 7.4%, 76.4% ± 9.6%, and 70.0% ± 9.6%, respectively. At the same time interval, the actuarial prevalence of grade 3+ CTCAE v3.0 toxicity was 26.1%. Conclusion: While the routine clinical use of this exploratory schedule is discouraged, it may represent the basis for future developments.

Original languageEnglish (US)
Pages (from-to)489-495
Number of pages7
JournalStrahlentherapie und Onkologie
Volume186
Issue number9
DOIs
StatePublished - Sep 1 2010
Externally publishedYes

Keywords

  • Altered fractionation
  • Intensity-modulated radiation therapy
  • Oropharynx cancer

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Oncology

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